Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Which serum lipoprotein is found in the highest concentration and density?
|
Avg conc. in mg/dl: LDL> HDL> VLDL> chylomicrons
HDL>IDL>LDL>VLDL>Chylomicrons |
|
|
Describe the following class of lipoproteins in serum in terms of their composition (major components), electrophoretic mobility and function:
a. chylomicrons |
is a lipoprotein that transports triglycerides and cholesterol from intestines to tissue
components- B-48 (major one), A-IV, C-II, and E - secreted from intestine by epithelial cells first in lymph and then bloodL hydrolyzes their TG, making them FA and glycerol Chloymicrons (with exogenous TGs and the apoprotein B48) enter first the lymph then the blood |
|
|
Compare VLDL and chylomicrons-
|
2 main differences
1. VLDL has b100 and Chylomicron has b48 2. VLDL is made from TGs in the liver (endogenous) and Chylomicrons are made from the intestine (exodogenous) |
|
|
Describe the following classes of lipoproteins in serum in terms of their composition (major components), electrophoretic mobility and function
a. LDL (beta lipoprotein) |
Delivers cholesterol to tisues 80% to hepatic tissue and 20% to peripheral tissue
- electrophoretic mobility:Beta globulin - Has B100 - taken up by LDL receptors |
|
|
Describe the following classes of lipoproteins in serum in terms of their composition (major components), electrophoretic mobility and function
- d. high density lipoproteins (alpha-lipoproteins) |
- picks up cholesterol in blood vessels and delivers to liver and steroidogenic tissues
- Electrophoretic mobility- alpha globulin - secreted by liver and intestine |
|
|
Describe the following classes of lipoproteins in serum in terms of their composition (major components), electrophoretic mobility and function
- very high density lipoproteins (lipoprotein apoprotein) |
delivers TGs from dietary surgars in liver to peripheral tissue
- contains B-100 and picks up apoE, ApoC, Electrophoretic mobility: alpha2-globulins |
|
|
Describe the general structure and role of lipoproteins
|
-transporters of triglycerides and cholesterol in blood
- hydrophilic groups of phospholipids, cholesterol and apoproteins directed outward. - Soluble in the salt water-based blood pool. - Triglyceride-fats and cholesterol esters are carried internally, shielded from the water by the phospholipid monolayer and the apoproteins. |
|
|
Describe the roles and options HDL has...
Include individual role of LCAT (lecithin cholesterol acyltransferase) and CETP |
1. HDL can take the CII from chylomicron back to liver or CII and E from VLDL (converting it to IDL)
2. LCAT makes cholesterol into cholesterol esters to be transferred by CETP 3. CETP transfers it to VLDL (making it LDL) and takes TG from VLDL and gives it to HDL |
|
|
What is the role of LPLase (lipoprotein lipase) in lipoprotein metabolism
|
hydrolyzes the fatty acid form the TGs carried by either chylomicrons or VLDLs and is acitvated by apoC-II
|
