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31 Cards in this Set
- Front
- Back
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What enzymatic reaction does COX perform?
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Converts Arachidonic acid into prostaglandins
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What do prostaglandins do?
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Promote inflammation
Sensitize receptors to painful stimuli Protect the gastric mucosa Promotes Platelet Aggregation Kidney Vasodilation |
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COX 1 is called the _____ while COX 2 is involved in _____.
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"housekeeper"
mediating tissue injury |
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COX 2 is not involved in renal function.
T or F |
False
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Inhibition of COX 1 would cause:
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Gastric Erosion
Bleeding Tendencies Renal Impairment Protection against MI and CVA |
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Inhibition of COX 2 would cause:
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Suppression of inflammation
Pain Relief Fever Reduction Renal Impairment |
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How is acetaminophen different from the other NSAIDs?
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Lacks ability to suppress inflammation
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What is the difference between the first and second generation NSAIDs?
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First generation are the conventional NSAIDs that block COX 1 & 2
Second Generation NSAIDs block only COX 2 |
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What is aspirin?
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First generation NSAID
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Aspirin binds to COX (irreversibly/reversibly).
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irreversibly
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What are the uses of aspirin?
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Suppression of Inflammation
Reduction of Fever Suppression of Platelet Aggregation Prevention of Colorectal Cancer |
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Who should not use Aspirin?
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Children and teenagers with influenza and chickenpox
Pregnant women |
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What are the symptoms of Reye's Syndrome?
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Encephalopathy and Fatty Liver Degeneration
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What causes Reye's Syndrome?
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Use of Aspirin by children and teenagers with influenza or chickenpox
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What Pregnancy Category is Aspirin?
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Category D
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What pain is Aspirin ineffective against?
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Severe pain of visceral origin
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Why are COX inhibitors especially good for treating Dysmenorrhea?
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Inhibition of Prostaglandins that promote uterine contractions
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What are the adverse effects of aspirin?
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GI bleeding
Bleeding Renal Impairment Salicylism Reye's Syndrome Hypersensitivity Reactions |
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What are the signs of Salicylism?
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Tinnitus (ringing in the ears)
Sweating Headache Dizziness |
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What are the drug interactions of aspirin?
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Warfarin (increase bleeding)
Glococorticoids (GI bleeding) Alcohol (GI bleeding) Ibuprofen (reduce anti-plalet effects) |
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What are the signs of a Aspirin OD?
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Respiratory excitation followed by respiratory depression
Acidosis Hyperthermia Sweating |
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Other NSAIDs besides aspirin cause reversible inhibition of COX.
T or F |
True
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Other NSAIDs besides Aspirin can protect against thrombotic events.
T or F |
False
Other NSAIDs increase the risk of thrombotic events |
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What is the prototypic 2nd generation COX inhibitor?
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Celecoxib
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What are the adverse effects of Celecoxib?
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GI ulcers
Increase risk of MI and CVA Renal Impairment |
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What is the drug interactions of Celecoxib?
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Warfarin
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Acetaminophen is different from other NSAIDs in that it is:
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devoid of anti-inflammatory and anti-heumatic actions
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Where does acetaminophen work in the body?
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The CNS
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What are the adverse effects of acetaminophen?
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Severe Liver Injury
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What is the sign of acetaminophen overdose?
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Hepatic Necrosis
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What is the specific antidote for acetaminophen OD?
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Acetylcysteine
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