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31 Cards in this Set
- Front
- Back
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Strep. salivarius
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early colonizer (followed by S. mutans and S. sanguini)
colonize dental surface and gingiva gram POSITIVE |
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bacteroides
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colonize mouth around puberty w spirochetes
gram NEG |
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treponema denticola
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levels of oral spiroschetes are elevated in patients w periodontal disease
Gram NEG |
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veillonella
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anaerobic cocci
thrives in acidic caries.... slows the development of caries as it converts acidic products of other species to less acidic products Gram NEG |
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porphyromonas gingivalis
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oral anaerobe
chronic adult periodontitis Gram NEG |
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aggregatibacter actinomycetemcomitans
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oral pathogen w virulence factors
associated w localized aggressive periodontitis in young adolescents can cause bone loss |
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Lactobacillus
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dental caries
found in gut bacteria..usually symbiotic w humans GRAM POSTIVE |
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Coxsackie
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a hand, foot and mouth disease
symp: blisters on hand, foot, and mouth ssRNA complication: meningo-encephalitis no cure/ treat/ prevention age 0- 2 |
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HSV 1
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linear DNA encased in a protein capsid
hereptic gingivostomatitis symp: blisters/ ulcers bilaterally in the oral mucosa complication: encephalitis treat: no vaccine, drug: acyclovir |
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Varicella Zoster
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DNA
cause : chicken pox symp: liquid-filled blisters all over body complication: encephalitis and recurrent zoster vaccine is avilable, drug: acyclovir |
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Parovirus
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small ssDNA
cause: Erythema infectiosum symptoms: slapped cheek syndrome In pregnant women, infection in the first trimester has been linked to hydrops fetalis, causing spontaneous miscarriage. no prevention/treat |
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Epstein-Barr
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dsDNA
Herpes virus 4 - one of most common viruses in humans "hairy tongue" infects epithelial cells w a cytolytic infection and B lymphocytes w a latent infection causes infectious mononucleosis ( glandular fever) |
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mucins
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secreted by submandibular/sublingual glands & minor glands
MG1 & MG2 glycoproteins - protein core w many oligosaccharide side chains attached to O-glycosidic bond more than 40% carbohydrates hydrophilic, resists dehydration high elasticity and adhesiveness (promote elasticity and viscosity) lubricate soft and hard oral tissue part of the Acquired Enamel Pellicle eliminates bacteria by aggregating (swallow) |
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amylases
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need ca to start its activity ( calcium metalloenzyme)
digest activty (hydrolyzes alpha (1-4) bonds of starches maltose is major end-product (20% is glucose) parotid gland - 50% of protein in parotid saliva (during chewing, digests food) part of Acquired Enamel pellicle - in sol'n promote bacteria aggregation (GOOD) - absorbed in enamel, promote bacterial aggregation and digestion of starch (BAD - provides food for bacteria in biofilm) |
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Lingual Lipase
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secreted by major salivary glands
involved in 1st fat digestion - hydrolyzes medium - long chain triglycerides highly unsoluble and enters fat globules imp in newborn milk fat digestion |
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statherins
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present in parotid and submandibular
v.small protein , many functions has PHOSPHOserines at positions 2 & 3 (N-terminal) - biological function at end supersaturation of CaPo4 maintains enamel integrity - statherins prevent precipitation/crystallization of supersaturated CaPo4 in ductal salvia -lubricant acquired Enamel Pellicle formation |
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proline-rich proteins (PRPs)
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40% is proline
inhibits CaPo4 crystal growth Acquired Enamel Pellicle precursor protein acidic, basic, & glycosylated |
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Acidic PRPs
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parotid & submandibular
2 PHOSPHOserines at position 8 & 22 ( in N-terminal) - biological function no carbohydrate 6 major proteins - diff at position 4 after N-terminal binds to enamel/HA absorption, bacterial binding in rest of protein - BAD! precursor of Acquired enamel pellicle formation modulate organization of bacterial colonization/ oral biofilm inhibit crystal growth ( secondary precipitation) effect decay and remineralization |
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Basic PRPs
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- secreted by all major glands
function unknown Acquired Enamel Pellicle - enamel homeostasis |
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Basic PRPs glycoprotein
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secreted by all major glands
lubrication bacterial interaction - promote swallowing of bacteria |
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lysozyme
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in many organs and body fluids ( ie saliva)
secreted by parotid and submandibular aka muramidase hydrolyze beta(1-4) bond in peptidogylcan layer of bacteria |
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muramidase
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aka lysozyme
in many organs and body fluids ( ie saliva) secreted by parotid and submandibular aka muramidase hydrolyze beta(1-4) bond in peptidogylcan layer of bacteria |
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histatins
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secreted by major and minor
-histidine rich antifungal & bacterial potent antifungal - KILL Candida albicans (histatin 5), inhibit Canadida albican growth (histatin 3 - biological function in "middle") - ONLY IN SALIVA inhibit demineralization (Histatin 1: phosphorlyated at position 2 (N-terminal) binds enamel and prevents tooth decay & ppt) 3 major: 1, 3, 5 |
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cystatins
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secreted from submandibular and sublingual
inhibit cysteine-proteases in many body fluids protective against bacteria proteases part of Acquired Enamel pellicle inhibits crystal growth |
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Lactoferrin
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binds IRON
salivary glands and gingival crevicular fluid inhibits growth of micros by depriving of iron |
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Salivary peroxidase
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sailoperoxidase - from major glands
myeloperoxidase - from leukocytes entering via gingival crevice 1. kill bacteria 2. protect host cells from h202 toxicity |
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Salivary Immunoglobulins
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IgA
IgG IgM from salivary glands and gingival crevicular fluid acquired enamel pellicle bacteria aggregation & swallowing |
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Uplink device
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sponge on top of tube, sponge expands when full of saliva
get out of sponge by pressing against cylinder tube - not good for detecting small MW proteins (like statherin) spit in tube better |
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Sarstadt - Salivette
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chew rolls (mech stimuli), put in tube
centrifuge cotton roll - need centrifuge in dental office |
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IDS UltraSal Device
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straw w 2 tubes
devide saliva to 2 tubes (1 tube you can freeze to -80 deg C) expensive tubes |
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Calypte-Aware Messanger
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press swab around gum line
send away |
