term1 Definition1term2 Definition2term3 Definition3
Please sign in to your Google account to access your documents:
Describe the means by which oxygen is dissolved in the blood (2 basic ways)
Dissolved in blood (1.5%)O2 has low solubility compared to CO2O2 carrying capacity in plasma = 0.3 ml O2/dL bloodBound to haemoglobin RBC (98.5%)[Hb] = 15g /dL
Haemoglobin Structure in adults and fetal types
Haem - Fe2+ containing moleculeGlobin – 4 polypeptide chainsAdult Hb A – 2α & 2β chain
Fetus Hb F– 2α & 2y (gamma) chains
2 states - oxyhaemoglobin & deoxyhaemoglobin
Terminology relating to O2 absorption
1. O2 pressure (PaO2)
2. O2 capacity
3. O2 content (CaO2)
4. O2 saturation
1. O2 pressure (PaO2) Amount of oxygen dissolved in plasma = 0.3 ml/dL
2. O2 capacity = Amount of O2 bound to Hb 15 g/dL x 1.34 ml O2 (x % saturation)= 19.7 ml O2/dL
3. O2 content (CaO2) Amount of O2 bound to Hb + dissolved O219.7 ml O2/dL (x % saturation) + 0.3 ml O2/dL= 20 ml/dL
4. O2 saturation The % of available binding sites bound to O2 . This stays constant with the PaO2.
O2 binding equation
O2 + deoxyhaemoglobin (Fe 2+) <--> oxyhaemoglobin
What is Methaemoglobin? Methemoglobinemia signs, symptoms
Methaemoglobin - haemoglobin in ferric state (Fe3+)Methaemoglobin reductase re
Need help typing ? See our FAQ (opens in new window)
Please sign in to create this set. We'll bring you back here when you are done.
Discard Changes Sign in
Please sign in to add to folders.
Sign in
Don't have an account? Sign Up »
You have created 2 folders. Please upgrade to Cram Premium to create hundreds of folders!