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-dronate suffix
DONATE box
Bisphosphonates
Two P coins = structure simiar to pyrophosphate
Large T-rex appetite = attach to hydroxyapatite in bone
Classmate(osteoclast) stuck in donate box = osteoclasts bind to biphosphonate inhibiting their adherence to bony surface
Preventing class from entering = Decrease developement of osteoclast precursors
Popping classmates balloon = induce osteoclast apoptosis
Elevated icecream = treat acute hypercalcemia
Disorganized bone display = treat paget disease
Standing on Massive calcified rock = treats hypercalcemia caused by malignancy
Calcitonin
Curator
Grabbing classmate = directly inhibits osteoclasts
Ice cream pouring down flank = promotes Ca2+ excretion by kidney
standing on Massive calcified rock = treats hypercalcemia caused by malignancy
Fallen icecream = can cause hypocalcemia
-dronate suffix side effects
Corroded neck = Can cause upper GI side effects avoided by taking water and standing upright
Crumbling Jaw = Can cause osteonecrosis of the jaw
Falling Icecream = Can cause hypocalcemia
Estrogen therapy
Female Cavewoman and symbol = Can prevent postmenopausal osteoporosis but increases risk of breast cancer
Female gaurding waiting class = Inhibits differentiation of osteoclast precursors
Raloxifene
Relax sign held by woman
selective estrogen receptor modulator (SERM)
treatment and prevention of postmenopausal osteoporosis
Relaxing the waiting class = estrogen agonist (inhibits osteoclast differentiation) and antagonist in breast and uterus (reduced risk of breast cancer)
Parathyroid Hormone
P(T)hD
Convices osteobuilder to give crank drill = stimulates osteoblasts to express RANKL
Crank drill = nuclear factor kappaB ligand (RANKL)
Active classmate with crank drill = RANKL binds to RANK on osteoclast, increasing activity
Denosumab
Dino suit man grabbing drill away
Antibody spikes = is a monoclonal antibody against RANKL
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