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The order of prevalence of the three bacterial causes of STDs in the United States is:
Chlamydia trachomatis > Neisseria gonorrhoeae > Treponema pallidum
This gram-negative obligate intracellular bacterium is among the most common bacterial infection in the US. It is encountered by humans only through sexual contact/birth. It enters at the genital tract, anal, columnar epithelium. The damage is often asymptomatic and inflammation. It is diagnosed through PCR and treated with antibiotics.
Chlamydia trachomatis
Which of the following describes the relationship between elementary bodies (EBs) and reticulate bodies (RBs) of Chlamydia trachomatis?
EBs are infectious
RBs are replicative
Which of the following is unique to Neisseria gonorrhoeae strains that cause disseminated gonococcal infection?
sialylation of LPS
This gram-negative diplococcus enters the genital tract, oral, anal, and ocular. It does not have to spread but some strains invade causing Disseminated Gonococcal Infection (DGI). It usually causes inflammation, purulent exudate, and is most often asymptomatic. It is also diagnosed through PCR and treated with antibiotics
Neisseria gonorrhoeae
The symptoms tertiary phase of syphilis is caused by:
host cellular responses to systemic infection
This very labile gram-negative spirochete has a very complicated disease process. It can be encountered not only sexually but congenitally as well. It enters through the genital tract mucous membrane and epidermal abrasions. It has periplasmic flagella that help with spread. It causes vasculitis, and is diagnosed by serology and treated with antibiotics although not the tertiary phase.
Treponema pallidum (Syphilis)
List the complex disease process of Treponema palladium:
Primary: local chancre (3 weeks)
Secondary: disseminated mucocutaneous skin lesions (3 months)
Latent (years)
Tertiary: bone, blood vessels, brain, gummas
Congenital: lethal, defects
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