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What is the mechanism of action for stimulants?
Cocaine: blocks dopamine reuptake proteins so increase in dopamine.
Amphetamines: block dopamine and norepinephrine reuptake proteins.
What is the mechanism of action for nicotine?
Stimulates specific acetylcholine receptors, called nicotine receptors, which in turn stimulate dopamine releasing neurons.
What is the mechanism of action for opiates?
Inhibits GABA neurons that would normally inhibit dopamine releasing, so increase in dopamine.
What is the mechanism of action for marijuana?
*Stimulates cannabinoid receptors on presynaptic neurons that release glutamate or GABA. (Reverse transmission). So, can be excitatory or inhibitory.
*Reverse transmission also at serotonin neuron that cause nausea
What is the mechanism of action for methylphenidate?
Block dopamine and norepinephrine reuptake proteins, this causes an increased concentration of dopamine in the synapse.
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