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physical incompatibilities
occurs from changes in solubility; which may result in changes in color or the formation of a precipitate. a change in the pH of a solution, the use of buffers, and the type of solvent used may create problems.
chemical incompatibilities
chemical reaction between one or more of the ingredients. incompatibilities may not be noticeable. changes is pH or chemical decomposition may occur. the presence of light may cause deterioration of the ingredients. IV medications are normally prepared using D5W, except ampicillin, ampicillin/sulbactam, erythromycin, lactobionate, imipenem-cilastatin, and oxacillin, which must be mixed with normal saline.
therapeutic incompatibilities
the mixing together of two or more ingredients, resulting in a change in the therapeutic response of the drugs.
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