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Glucocorticoid
-affects intermediate carb metabolism
-major present in body: cortisol (hydrocortisone)
-w/out stress body produces 20mg daily
-MOA: binds to specific receptor & forms a steroid-receptor complex
-⬇️ growth, ⬇️ glucose use, ⬆️ gluconegenesis, membrane function, enzyme action, anti-inflammation, carb metabolism
-not curative, palative for symptoms mine
Mineralocorticoids
-affects water & electrolyte composition in body
-effects: has lag time
-⬆️ sodium retention, ⬆️ potassium loss, edema & hypertension adverse
Adverse reactions
-metabolic: moon face, truncal obesity, buffalo hump
-infection
-peptic ulcer
-CNS: personality changes, depressed, euphoria
-⬆️ ophthalmic pressure
-adrenal crisis
-oral: slow healing, candidiasis
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