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This disease is characterized by only one functional alpha hemoglobin gene and marked decrease in the synthesis of alpha chains
This disease occurs mainly in Asians, has symptoms caused by accumulation of excess beta globin, causes extravascular hemolysis, and anemia with splenomegaly:
This condition results from deletion of all 4 alpha hemoglobin chains and leads to intrauterine fetal death
Lab results for this condition are high total rbcs, low MCV, and normal RDW.
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