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Four Stages of Gout
Asymptomatic hyperuricemia-Puberty in men and menopause in women
Acute Arthritis-After several years. Acute pain. 50 %in first metatarsophalangeal joint.
Asymptomatic intercritical period- symptom free interval
Chronic tophaceous gout-Develops about 12 years after acute attack. Radiography show juxtaaeticular home and loss of joint space.
Uric acid is the end product of
Purine production
What are the two pathways of purine nucleotide production?
De Novo: Purine nucleotides are synthesized from nonpurine precursors
Salvage: Synthesized from free purine bases through diet or catabolism of purine nucleotides
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