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What are the 5 biogenic amines?
Dopamine, norepinepherine, epinepherine, serotonin, histamine.
Where can acetylcholine be primarily found?
Neuromuscular junctions.
What is the precursor to acetylcholine?
Acetyl coenzyme A (synthesized from glucose), and Choline.
What is acetylchole catalyzed by?
CAT.
What is acetylcholine taken up by for synthesis?
ChT
What is acetylcholine postsynaptic effect?
Excitatory.
Where is the angry provided for acetylcholine creation?
Acidic PH of the vesicle lumen, which allows AcH reancporter (VACh) to exchange hydrogen for acetylcholine.
How is Acetylcholine terminated?
NOT MY REUPTAKE, but by hydrolytic enzyme (AChE). AChE breaks ACh down into acetate and choline. Choline is recycled by transport back into the nerve terminal, where it is used to synthesize ACh.
What drugs react with acetylcholine?
Organophosphates: Sarin, which can be lethal because it inhibits AChE, allowing ACh to accumulate at cholinergic synapses.
How does Sarin work?
Inhibits Ache, depolarizing the postsynaptic cell, rendering it refractory and causing neuromuscular paralysis. It is often used in insecticides, because insects are highly sensitive to this.
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