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Methods to Assess Tumors for Mutations, etc.
Chromosomes: Karyotype, Array CGH, FISH
Sub-microscopic DNA mutations: Allele specific PCR, qRT PCR, Pyrosequencing, Southern Blot/MLPA, Sanger sequencing, Next gen. seq.
Epigenetic: Hypermethylation Analysis
RNA: Expression arrays, Rev. Transcriptase PCR
Protein: Immunohistochemistry
Detection of molecular biomarkers in order to
- Detect cancer
- Determine prognosis
- Monitor disease progression
- Monitor therapeutic response
NGS (Next Generation Sequencing) / Massively Parallel Sequencing
Genomic DNA
-> fragmented library of DNA pieces all sequenced at the same time
-> individual reads aligned to reference sequence
=> whole-genome sequence (~ consensus of aligned reads)
Personalized Medicine
Is the best.
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