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- Term referring to the scientific study of a disease
- Structural and functional changes brought about the disease and their effects on the body
- Fist concerned with the cause (etiology) and second its development (pathogenesis), third the structural and functional changes brought about
- Term referring to the development of a disease
- May exist in the absence of a detectable disease
Ex: AIDS
- An abnormal state in which the body is incapable of performing normal functions
- Transient
- Normal
- ____________ Microbiota may be present for days, weeks or months (Short periods)
- ____________ Microbiota permanently colonize the host in certain regions and do not cause disease under normal conditions. Some are opportunistic pathogens.
- Nutrients
- Physical and Chemical Factors (Temperature, pH, O2 & CO2, salinity, sunlight)
- Host Defenses
- Mechanical factors (Saliva, urine, chewing)
- Competition between microbes, natural flora is "fighting the fight" for the body
Ex: Normal microbiota protect the host by competing for nutrients, producing substances harmful to invading microbes, affecting pH and available oxygen; probiotics help, antibiotics may backfire by destroying natural flora
- Infection: Colonization - Pathogen residing in or on you
Disease: Abnormal State - Pathogen is actually affecting the body
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