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What disease of the hooves is characterized by failure of the attachments between the coffin bone and inner hoof wall?
Laminitis (Founder)
Laminitis is a _______________ (systemic/local) manifestation of a _____________ (systemic/local) issue?
LOCAL manifestation of a SYSTEMIC issues
What are the 3 main disease states that are assoc'd with laminitis?
1) Endotoxemia/sepsis
2) Equine metabolic syndrome
3) Supporting limb laminitis
What does the ingestion of or use of as bedding cause laminitis?
Black walnut
How does the pathogenesis of laminitis occur with the vasoconstriction theory?
Vascular damage -> ischemia -> coagulopathy -> increased blood flow to hoof w/ DECREASED capillary perfusion -> ISCHEMIA IN HOOF -> pain! -> inflammatory mediator release -> more ischemia -> loss of support between dermal and epidermal laminae -> separation of distal phalanx (P3) from hoof --> epidermal hyperplasia of laminae- wedge
What is the enzymatic theory of laminitis development?
Vasodilation of hoof vessels -> triggers coming in to lamellar tissue (cytokines)? -> lamellar disintegration ->
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