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What do PRRs do?
Detect PAMPs
What are the 3 places PRRs are expressed?
Give examples.
Cell surface - Toll Like Receptors (TLRs) and C- type Lectin Receptors
Cell endosomal (vesicular) system - Toll-Like Receptors
Cell cytosol - NOD-Like Receptors (NLRs), RIG-Like Receptors (RLRs) and DNA Sensing Receptors (DSRs)
What do TLRs do?
Detect bacteria and viruses PAMPs
What do CLRs do?
Detect fungal and microbial sugars
What do NLRs do?
Detect bacterial PAMPs and their toxins
What do RLRs do?
Detect viral RNA
What do DSRs do?
Detect viral/bacterial DNA
What does TLR-4 detect?
Lipopollysaccharide (LPS) - cell wall component of Gram negative bacteria
What does TLR-2 detect?
Lipoteichoic acid (LPA) - a cell wall component of Gram positive bacteria
Which TLRs are expressed on the cell surface?
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