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What is a half life?
the time taken for the plasma concentration to fall by half.
the time taken for the amount of drug in the body to fall by half.
it increases as the elimination rate constant increases.
What happens to half life as clearance increases
it decreases
what happens to half life as the volume of distribution increases
it increases
After a single dose of a drug which has a half-life of 12 hours, what percentage of the dose is still in the body after 1 day?
25%
During a constant rate intravenous infusion of a drug with an elimination rate constant of 0.173 per hour, the plasma drug concentration will be what percentage of steady state after 16 hours.
steady state after 16 hours so half life is about 4 hours table on page 19 gives us the answer of 93.75
half life determines
bde
the time to reach steady state
the duration of action after a single dose
the fluctuation in plasma drug concentration during a dosing interval
What are the major routes of drug elimination from the body?
excretion as unchanged drug by the kidneys
and
elimination by metabolism in the liver
What is hepatic extraction ratio
the fraction of the drug entering the liver in the blood which is irreversibly removed/extracted during one pass of blood through the liver
range of possible values of hepatic extraction ratio
0 to 1
Which two factors determine the clearance of a drug by the liver?
rate of delivery of drug to the liver determined by the hepatic blood flow
the efficiency of removal of drug which is presented to it (the extraction ratio)
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