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How are phagocytes recruited to an infected area?
Phagocytes go through 2 phases of migration to reach the infected area.
1. Margination- phagocyte sticks to endothelium (lining) of blood vessel.
2. Diapedesis- phagocyte squeezes between endothelial cells to reach infected area.
What are the signs and symptoms of inflammation?
- redness (vasodilation)
- swelling (vasodilation, blood vessel fluid leakage, increase in cell number)
- heat (vasodilation, increase in cell activity)
- pain (damage, pressure, increase nerve sensitivity)
What is the complement system?
The compliment system is a protein based antimicrobial defense system. Involves over 30 different proteins and acts in a cascade (one reaction triggers another, amplifying the effects)
- cascade for active C3
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