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What is the most prevalent disease that affects synaptic transmission?
Myasthenia gravis
What do the antibodies produced do?
Interfere with synaptic transmission by reducing the number of functional receptors or by impeding the interaction of ACh with its receptors
How does the brain look at autopsy?
CNS and PNS look normal, so disorder of function
Describe the amplitude of evoked compound action potentials in MG.
Decreases rapidly like when curare is applied
What do 15% of adult patients with MG have and what does it imply?
A benign tumor of the thymus
Suggests MG is an immunological disorder
What toxin would you use to isolate ACh receptors?
alpha-bungarotoxin
How would you determine how many binding sites on receptors are open?
Radiolabeled alpha-bungarotoxin
What are the essential characteristics of MG?
1) Reduction in amplitude of the miniature end-plate potentials
2) Smoothing of the normal convoluted appearance of the postjunctional folds
3) A loss of ACh receptors from the crests of junctional folds
4) Deposition at junctional sites of antibody and complement
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