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What are two major types of chemical transmission?
Direct and indirect
What is the best system to study direct receptors?
The neuromuscular junction
What are the benefits of studying the neuromuscular junction?
The muscle cell is large enough to accommodate several microelectrodes for electrophysiological measurements
Postsynaptic membrane can be visualized with the light microscope in a living cell
Muscle fiber is innervated by only one motor axon
What is the transmitter released at the neuromuscular junction?
ACh
What receptor type is in the muscle membrane?
The nicotinic type of ACh receptor
What is the end-plate?
The motor neuron's axon innervates this specialized region of the muscle membrane
Does the axon have myelin at its end?
No
Does the axon branch?
Yes
What are synaptic boutons?
Multiple grape-like varicosities that are the ends of the branches of the axon, where transmitter is released
What are junctional folds?
A depression in the surface of the muscle fiber where the membrane of the muscle fiber forms deep folds; corresponds to a bouton
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