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Red Cell Production
Define as dynamic process that originates from pluripotent stem cells, appealing due to their adaptability, they respond to programmed chemical environment, committed RBC cell line, and Erythroblast. Largest living cell from bone marrow.
Red Cell Changing During Maturation
Occurs in a period of 5 days, each precursor cell goes through three successive divisions. Cells sized reduced, nucleus is baseball around. Nuclear: cytoplasm ratio decreases. Nuclear chromatin becomes more condensed and cytoplasm color changes from blue to pink/salon as hemoglobin synthesized. Mature red blood cells is a nucleated.
Erythrocytes
clusters in specific areas during maturation. Easily identified in the blond marrow aspirated by certain morphologic clues, extremely round nuclear material along with basophilic cytoplasma
Mature vs Immature RBCs
Size : Immature Large Mature Small
Cytoplasm Color: Blue // Salmon
Nuclear Shape: Baseball Round //
Nucleus: Yes /// No
N:C Ratio: High /// Low
American Society of Clinical Pathologist
ASCP - Rubriblast
ASCP - Prorubricyte
ASCP- Rubricyte
ASCP - Metarubricyte
The College of American Pathologist
CAP - Pronormoblast
CAP - Basophilic normoblast
CAP - Polychromatophilic normoblast
CAP- Orthochromic normoblast
6 Maturation Stages
1. Pronormoblast 2. Basophilic normoblast. 3. Polychromatophilic normoblast. 4. Orthochromic normoblast, 5. Reticulocyte, 6. Erthrocyte
Pronormoblast
18-20 nm
N:C 8:1
Nuclear chromatin , round nucleus, densely packed chromatin, evenly distributed fine textures with deep violet color
Basophilic normoblast
16 nm
N:C 6:1
Nuclear Chromatin : Round nucleus, crystalline chromatin appearance, red-purple color
Cytoplasm: Cornflower blue with indistinct area of clearing
Polychromatophilic Normoblast (first stage of hemoglobin synthesis)
13nm
N;C 4:1
Nuclear Chromatin: condensed, moderately compacted
Cytoplasm: Color mixture, blue layers with traces of orange-red, hemoglobin synthesized
Orthochromatic normoblast (most nRBCs seem in blood at this stage, Hgb synthesis still occurring)
8nm
N:C 1:1
Nuclear chromatin: dense, velvet-appearing homogeneous chromatin
Cytoplasm: increased volume with orange -red color shades with slight blue tone
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