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How Apc/c and scf are regulated??
What are cdc20 and cdh1 ?
The substrate specificity of active, phosphorylated APC/C is determined in part by its association with one of two related substrate targeting factors called Cdc20 and Cdh1. During anaphase, APC/C bound to Cdc20 ubiquitinylates proteins that inhibit chromosome segregation, while during telophase and G1, APC/C bound to Cdh1 targets different substrates for degradation.
What is the Sic1 homologue in metazoans called?
p27
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