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Mutation in CD 18
Leukocyte Adhesion Deficiency (LAD)
- No intergrins = no tight binding = increased circulating neutro's and no neutro's in inflammed tissue
Mutated NADPH oxidase
Chronic Granulomatous Disease (CGD)
No resp. burst in Neutros -> recurrent bacterial/fungal ifxns
GM-CSF treated Neutro w/ Toxic Granulation
-"May-Hegglin Anomaly" = Dohle Bodies (RER remnant), large granules, vacuoles, L-shift
Toxic Degranulated Neutro due to sepsis
- Same as GM-CSF treated but have bacterial inclusions
Chediak-Higashi Syndrome
- recessive mutation causing abnormal degranulation w/ large aggregated inclusions, pancytopenia, and recurrent pyogenic ifxns
Mutated RAS
Signal-transducer oncogene
- causes no GTP hydrolysis = continual growth signals
Deletion of 17q
Li-Fraumeni Syndrome
- inherit one mutation of p53 (detects DNA damage -> activates p21 to inhibit cycD/CDK4)
* Increased risk of cancer
CD45
WBC
CD34
Stem Cell
CD2-8
T-Cell
(Immature = Neg for 4 & 8, Int = Pos for 4 & 8, Mature = Pos for 4 or 8)
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