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What are the 3 classes of calcium channel blockers (CCBs)
Dihydroptridone: e.g. nifedipine and amlodipine (vascular effect) - most commonly used
Non-Dihydropyridine: (Phenylalkylamines) verapanil - not used much anymore
Benzothiazepine: e.g. diltazen
What are the pharmacokinetics of Nifedipine?
Bioavailability: 45%-55%
Metabolism (first pass effect): GI and hepatic
Half life (time taken for initial dose to halve in bloodstream: 2 hours
Side effects of vasodilators
Hypotension
Headaches
Flushing
Palpitations
Bradycardia
Oedema
Constipation
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