term1 Definition1term2 Definition2term3 Definition3
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Ventral Corticospinal Tract
Trunk, thigh
Lateral Corticospinal Tract
Hand, foot
Basal Ganglia
Associated with functions including: control of voluntary motor movements, procedural learning, routine behaviors, eye movements, cognition and emotion.
Huntington's Disease
Striatal inhibitory neurons of the indirect pathway degenerate, leading to insufficient inhibitory output of GPi and excessive movement generation.
Parkinson's Disease
The dopaminergic neurons of the SNc degenerate, unbalancing their modulatory effects on the striatum (putamen and caudate nucleus). Direct pathway output of the striatum is weakened and indirect output is strengthened, leading to excessive inhibitory output of GPi, suppressing movement generation.
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