term1 Definition1term2 Definition2term3 Definition3
Please sign in to your Google account to access your documents:
4 stages of Age Related Macula Degeneration (AMD)
Early AMD: several small drusen, few medium sized drusen
Intermediate AMD: many medium drusen, at least one large drusen
Advanced Non-Neovascular AMD:
Many drusen and atrophy into macula
Advanced Neovascular AMD: Choroidal neovascularisation
Pathogenesis of Non-exudative (Dry) AMD
RPE is responsible for waste removal from the outer segments of the rods and cones
Extra cellular lipid deposits build up in RPE, excess material transferred to Bruchs membrane in the choroid
Oxidative stress from aging causes changes in Bruchs membrane and choriocapillaris
Drusen begins to appear
RPE shows degenerative changes that are not being replaced
The photoreceptors then degenerate