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Polyene antibiotics
Binds to ergosterol in cell membrane. And increases membrane permeability. Leakage of intracellular content. Death of fingi.
Amp B, Nyacin, Hamycin
Heterocyclic antibiotics
Interact with polymerized microtubules. Disrupts mitotic spindles. Spindle poison inhibits fungal mitosis
Griseoflavin
Azoles inhibit ergosterol synthesis inhibiting 14@ demethylase enzyme.
Dermatophytic infections. Candida infections
Imidazoles:- Ketakonazole, micanozole, clotrimazole
Triazoles. :- Flucanazole, Itraconazole, Voriconazole
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