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TCA
Block NT reuptake
Block other receptors
Clomipramine
Amitriptyline
Imipramine
TCA Uses
Tx:
Depression severe
Panic
Neuropathic pain
Nocturnal enuresis
TCA AE
1. Anticholinergic-Constipation, Urinary retention, Blurred vision, narrow Angle glaucoma, Xerostomia
2. Sympatholytic ; postural hypo, reflex tachycardia
3. Histamine ; sedation
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