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33 Cards in this Set
- Front
- Back
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3 main components of connective tissue
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Ground Substance
Fibers Cells |
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Ground Substance Composition
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Proteoglycans - GAGs
Glycoproteins - Laminin (Basal Lamina) and fibronectin Tissue Fluid |
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Hyaline cartilage type
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Type II
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Major types of fibers
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Collagen (I), Elastic (II), Reticular (III)
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Collagen (I) Stain w/ H&E
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acidophilic pink
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Type I Collagen
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Bone, tendons, CT of skin, ligaments, fascia, organ capsules
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Type II Collagen
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Elastic and Hyaline cartilage; IV disc
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Type III Collagen
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Reticular fibers, loose CT, smooth muscle
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Type IV Collagen
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Basal Lamina
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Type VII Colagen
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Anchoring fibrils (attach BL to CT fibers)
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Type X Collagen
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Produced by chrondrocytes in zone of hypertrophy of normal growth plate (bones)
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Key feature of collagen fibers in electron micrograph:
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Periodicity
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Ehler Danlos
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"Stretchy elbow"; defect in procollagen peptidase. Collagen
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Marfan's
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abnormal elastic tissue (bad fibrillin). Cardiovascular abnormalities
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Staining of elastic fibers
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orcein or resorcin-fuchsin
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Elastic Fiber Composition
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Elastin and microfibrils made up of fibrillin
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Reticular Fibers
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Type III. Thin, form framework for organs (lymph, spleen). Silver Stain
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Connective Tissue Cells, main types
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Resident and Immigrant
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Resident Cell Types
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fibroblasts, adipose, special CT cells
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Immigrant Cell Types
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mast cells, plasma cells, leukocytes (nutriphills, eosinophils)
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Fibroblasts
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Most abundant cell in CT. Make extra cellular matrix (ground substance and fibers).
[Makes collagen] |
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Adipose Cells
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White fat(unilocular), Brown fat (multilocular).
Have basal lamina. Mesenchymal cell origin |
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Mast Cells
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Large, ovoid cells with many granules.
Hemopoietic origin Granules have histamine, eosinophil and neutrophil attractant factors, heparin. |
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Plasma Cells
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Cells produce antibodies, derived from B-Cells
Common in loose CT of gut and glands Appearance: Basophilic (rER), Clockface, clear golgi app. |
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Macrophages
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Cells derived from monocytes in blood.
When phagocytically active, they have large vacuoles in cytoplasm |
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Giant Cell
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Multiple macrophages fused together in response to foreign body
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Lymphocytes
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Part of immune surveillance system
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Neutrophils
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First cells to arrive at a site of acute inflammation.
Active phagocytes Pus is an accumulation of dead ones. Appear with segmented nuclei. |
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Eosinophils
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Bilobed nucleus. Named because of large red granules.
Part of: allergic, parasitic, chronic inflammatory processes. Found in lamina propria of gut |
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Types of CT classification
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Loose CT, Dense (regular + irregular) CT
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Loose CT
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Underlies Most epithelia
Found around glands Cells: mast, plasma, macrophages, lymphocytes, fibroblasts |
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Dense Irregular CT
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Fewer cells, mostly fibroblasts
More fibers, organized in different directions to tolerate multidirectional stress |
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Dense Regular CT
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Fewer cells, mostly fibroblasts
Organized in same direction, unidirectional stress |
