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30 Cards in this Set

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Examples of Adipose Loose Connective Tisse
hypodermis, mesenteries, omenta, kidneys
Eg. of Reticular connective tissue
of framework bone marrow, spleen, lymph nodes
Eg. of Pigmented Loose CT
chroid layer of eye
Eg. of lamnia propria
mucosa of digestive, respirtory, urinary, and genital tracts
What germ layer is most connective tissue derived from? What is the Intermediate filament?
Mesodermal mesenchyme. Intermediate filament= vimentin

some CT in head is from ectoderm
Eg. General Loose CT- Areolar (fills spaces in body)
superficial fascia and embedding medium of many structures
4 Eg. of Regular Collgenous CT and purpose
(arrangement in parallel bundles intersperced with fibroblasts)
tendons, ligaments, aponeuroses, deep fascia. For trasmitting mechanical force
6 Eg. of Dense Irregular Collgenous CT
(complex woven pattern)
reticular layer of dermis, capsules of organs, dura mater, periostem, perichondrium and , septa and trabeculae of organs- resists tensil stress
Dense elastic CT
Vocal cords, ligamentum nuchae and flava
Musous CT- what is it made of and give examples
hyaluronic acid
eg. nucleus pulposus
Function of Intermediate Filaments
Tensile Strenght (toughest of cytoskeletal filaments)- they are rope like, 10nm diameter. Located all thorugh cell, cell periph, and anchored to cell-cell jxns. Fibrous proteins and non energy for polymerization
IF for epithelial cells and derivatives (hair and nails)
keratins- in cytoplasm
IF of mesenchymal origin (mesoderm)
vimentin and vimentin-like filaments (cytoplasm)
IF of muscle cells
Desmin- cytoplasm
IF of Glila cells eg. astrocytes, Schwann cells
Glial fibrillary acidic protein or GFAP
IF of Neurons
Neurofilaments (NF-L, NF-M, NF-H) - cytoplasm
All nucleated cells contain this IF
Lamin (A, B, C)-Lattice/mesh rather than rope like. Located in the inner side of the inner nuclear membrane
What are the three macromolecules that compose the extracellular matrix? What is their function?
1. glycoaminoglycans (GAGs) and proteoglycans- gel like resist force
2. Adhesive glycoproteins -bridge fibrous proteins and cells
3. Fibrous proteins- elastin-resiliency and collagen-strenght
(1 &2 are components of the ground substance)
What are glycosaminoglycans? What are their characteristics?
Long, inflexable unbranched, polysaccharide chains w/repeating disaccharide units . Most are sulfated and negatively charged, which makes them attract Na and H2O follows. This assists in the resistance to force and compression. When GAGs are covalently linked to proteins they are called proteoglycans
What is the function and distribulton of

Haluronic acid?
Resists compressive forces in tissues and joints.
Found in tissues and fluids, loose CT, skin, vitreous, and snovial fluid, and cartilage
GAG Chondroitin Sulfate
Location and function
Hyline and elastic cartilage, bone

Mechanical support
GAG Dermatan sulfate
Location and function
Dermis, tendons, ligaments, heart valves, epineurim (nerves), arteries, organ capsules, sclera, and fibrocartilage

Binds to type I collagen fibers
GAG Keratan sulfate
Location and function
Bone, cartilage, cornea

Mechanical support
GAG Herparan sulfate
Location and function
Fibroblast and epithelial cell surface, basal and external laminae

Cell adhesion; binds FGF, filtering and structural fxn of basal laminae
Proteoglycan Aggrecan

What are the GAGs that make them up and how do they promote cell adhesion?
Keratan sulfate and chondroitin sulfate

Cartilage
Proteoglycan Perlecan

What GAG makes it up and how does it express cellular adhesion?
Heparan sulfate

Composes Lamina Rara in all cells making basal lamina (epithelial, muscle, and nerve)
Glycoproteins have the ablilty to help cells adhere to extracellular matrix by binding to the cell surface via?
Integrins (at RDG sequence), collagen fibers, and proteoglycans
Glycoprotein Fibronectin
Location and function
extracellular structures- cell surface, basal laminae, and external laminae

Cell adhesion to integrins, Collagen I, II, IV
Glycoprotein Laminin
Location and function
Basal and extermal lamina of muscles

Bind to Type IV Collagen and herparan sulfate
Glycoprotein Entactin
Location and function
Basal laminae

Bind to Laminin and Type IV Collagen