Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
|
common pathway
|
c3->c5->c6->c7->c8->c9
MAC = 5-9 |
|
|
classical pathway
|
abag
c1q/2r/2s -> c1 -> c14b -> c14b2a |
|
|
mblectin pathway
|
MBL-MASP1-MASP2 -> MC4b -> MC42a
|
|
|
alternative pathway
|
iC3 + Factor B -> (Factor D) -> iC3Bb
rapidly degraded unless properdin --> C3bBbP [C5 convertase] |
|
|
c3a,c4a,c5a
|
anaphylatoxin
|
|
|
which ab can complement
|
igg not igg4 and igm
|
|
|
c1inh
|
binds c1r and c1s and blocks c1 complex
|
|
|
factor I
|
cleaves c4b
rapid inactivation of c3b |
|
|
factor H
|
factor I cofactor (c3b)
|
|
|
C4-BP
|
factor I cofactor
|
|
|
MCP (CD46)
|
cofactor for factor I
c3b inactivation |
|
|
DAF (CD55)
|
dissociation of c3/c5 convertases
|
|
|
S protein (vitronectin)
|
inhibits MAC insertion (c5b-7)
|
|
|
clusterin
|
inhibits MAC insertion (c5b-7)
|
|
|
CD59 (protectin)
|
inhibits MAC formation (c8-c9)
|
|
|
HRF
|
inhibits MAC formation (c8-c9)
|
|
|
cr1
|
dissociation of C3/c5, cofactor for c3b/c4b for factor I
|
|
|
factor J
|
inhibits c1 complex and Bb-mediated cleavage of c3.
|
|
|
cr1
|
c3b and c4b
cofactor for factor I cleavage of these |
|
|
alternative pathway deficiencies
|
neisseria meningitis
factors B + D = AR properdin = XLR |
|
|
classical pathway deficiencies
|
c1, c2, c4
AR glomerulonephritis & SLE |
|
|
MAC deficiencies
|
AR
c5-c9 neisserial infections |
|
|
def that cause PNH
|
DAF
CD59 HRF PIG-A defect acquired, not inherited. |
|
|
hereditary angioedema
|
c1-inh deficiency
(AD) |
|
|
c4BP deficiency
|
angioedema
behcet's like syndrome AR |
|
|
factor I/H deficiency
|
pyogenic infections
AR |
|
|
MBL deficiency
|
***AD***
URTI's. |
|
|
ch50 assay
|
classical pathway measurement
sheep rbc + commercial antibodies + patient serum activity = reciprocal of dilution that lyses 50% |
|
|
low ch50 means...(normal ah50)
|
low c1q/r/s, c2, c4
|
|
|
ah50 assay
|
rabbit rbc without ab
+ Mg/EGTA absorb serum with cold rabbit rbc 1st to remove nonspec |
|
|
low ah50 means...(normal ch50)
|
low properdin (common)
low factor B or D |
|
|
low ah50 + ch50 means
|
low c3/c5/c6/c7/c8/c9
|
