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19 Cards in this Set
- Front
- Back
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vascultiis
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large vessels:
Giant cell, takayasu medium vessels: Polyarteritis nodosa, kawasaki, thromboangitis obliterans small vessel: henoch schonlein purpura, hypersenstivity arteritis, churg straus, microsopic polyangitis, thrombangitis obliterans |
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hypersensitivity arteriits
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type III HPS to drugs, tumors, HCV, HBV, HIV
+ P-ANCA affects:SKIN, muscel brain kidney cause purpura, painful, puritic |
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henoch schonlein
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IgA immune complex deposits on small vessel walls
children palpable purpura (butt), athralgias, bloody diarrhea +/- glomerulonephtritis |
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Polyarteritis nodosa (PAN)
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Trasnmural necrotizing inflammation of arterial wall
WBC invade blood vessel secondary to HBV, HCV, hairy cell leukemia fever, abdo pain, melena, renal dis (w/out glomerulonephrits) w/HTN, neuritis of motor neuron |
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Microscopic polyangitis
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usuallly initiated by rxn to drugs (penicillin)
+ P-ANCA cause severe glomerulonephritis-->RPGN and pulmo capillaritis palpable purpura, hemoptysis, hematuria myalgia |
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thromboangiitis obliterans (buergers dis0
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HPS to tobacco
high in jewish, young males, smoker tibial and radial arteriis: PMN surronded by granuloma-->cause blood vessel obstruction-->severe pain in distal limb-->gangrene |
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Giant cell artertiis
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granulomatous inflammation of vessel walls
large vessel: aorta, carotid, vertebral, temporal temporal arteritis: fever, temporal headache, fatigue, hi ESR-->if left untreated-->sudden monoculr blindness TX: immediately start steroid therapy in suspected temoral arteritis (dont wait for labs) females>50 yo |
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Polymyalgia rheumatica
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systemic manifestation of giant cell arteritis
flu like symps wiht arthralgia, myalgia (axial skeleton) fever, very high ESR may lead to: claudication, CVA, MI, aortic anyrysms, organ infarction. |
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WEgners granulomatosis
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+ c-ANA
sinusitis, glomerulonephrits-->RPGN, lung lesions sinus polyp formation |
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Takayasu arteritis (aortic arch syndrome)
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thickining or aortic arch with huge granuloma formation
peak: 15-40 yo females of asian desent night sweats, chest pain, weak peripehral pulse, eventual organ ischemia |
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Kawasaki dis (mucocutaneous lymph node syndrome)
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Similar to PAN,
triggered by viral illness fever (greater than 5 days), conjuntivitis, maculopapular rash (hands and soles), CORONARY ARTHERY ANEURYSMS, oral mucosal erythema and cervical lymph node elargement LEADING CAUSE OF ACQUIRED HEART DIS IN CHILDREN OF JAPAN AND US FIRST LINE TREATMEN: IVIG + ASPRIN |
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Churg strauss (allergic angiitis)
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granulomas, PAN like histologic in vessel wall, MASSIVE EOSINOPHIL invasion in vessel wall and surrounding tissue
+ p-ANCA vessel of skin, nerves, muscle +LUNG + HEART casue severe ASTHMA like attacks + lung infiltrates mostly confined to occuring in patients wiht HX of ashma |
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Behcet's syndrome
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vasculits of VEINS AND VENULES
recurrent painful and oral ulcers (mistaken for herpes) +/-uveitis/iritis, arthritis or knee brain and GI damage high risk of DVT's adn PEs descendent from mediteranion, middle east, far east (silk route) BLACK ARE NOT AFFECTED males gert much more SEVER DIS ANTI-HUMAN ORAL MUCOSA ANTIBODIES |
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syphilitic aneurrysm = leutic aneurysm
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in tertiary aneurysm
trepenoma pallidum causes oblitreateiv endarteritis of vaso vasorum of throaci aorta-->ischemia-->atrophy of media-->intima buckles-->appearance to tree barking of the intima may casuse aortic regurgitation |
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berry aneurysm
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most common type of intracranial aneurysm
aneurysm of circle of willis more common in adule polysystic kidney dis may rupture due to HTN-->subarachnoid hemmorrhage |
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Aortic dissection
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intima tears-->and split occurs between laminar planes of media-->collection of bood within the aortic wall
risk factor: HTN, MARFANS' 2 classification: stanford classification: Type A: any dissection that involves ascending aorta type B: any aorta discection that doesnt invlolve ascending aorta Debakey classividation: type I: ascending aorta +descending aorta Type II: any aortic discention without any part of descending aorta involvement. Type III: any aortic discention without any part of ascenting aorta involvement (same as type B). |
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Micro aneurysm
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small cerebral aneur due to HTN
small retinal anuer secondary to diabetes |
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Mycotic
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due to infx of vessel wall usually bacterial-->damage media-->wall weakening
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aneurysms of Aortic arch
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signs and symps of bulging:
-dyspena due to compression of resp. structures -recurrent, persistent cough due to pressure on recurrent laryngeal nerves -heart failure if aneursm caused aortic regurgitaion -rupture and death |
