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23 Cards in this Set
- Front
- Back
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autoimmune hemolytic diz
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Anti-RBC
warm AB: IgG, severe anemia, splenomegally, High MCHC(more HgB/RBC even though loss of blood volume)*: lifelong, temp>37, central body Cold AB: IgM, anemia, Raynauds, acrocyanosis(hands, toes, scrotum) |
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Bullous pemphigoid
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Anti-epidermal Basement membrane
cause: bullae (between epidermis and BM), puritis, elederly |
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Type 1 DM, insulin-dependent DM
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Anti-islet cells
cant make insulin hyperglycemia, DKA risk, infections, retinopathy, nephropathy, atherosclerosis, neuropathy (loss of pain sensation) |
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pemphigus
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anti-keratinocyte jnx in epiderm.
nikolsky's sign, oral and skin ulcers, older >_55 vesicles form in the epidermis |
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pernicious anemia
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anti-intrinsic factor, antiparietal cell
must have type A (autoimmune) gastritis before. megaloblastic anemia, gastritis, vitamin B12 deficiency |
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polyarteritis nodosa
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inflamation of medium sized arteries. Tetrad; fever, HTN, abdominal pain, renal dis. (w/out glomerulonephritis because glomeruli are small vessels and capilaries)
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microscopic polyangitis
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P-ANCA (perinuclear-antinuclear cytoplasm antibodies)
affects small blood vessels including caps. hemoptysis (lungs served by small caps), hematuria (kidney caps rupture), palpable purpura(small caps in skin rupture) (with glomerulonephritis because small caps in glomeruli) |
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polymyositis
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anti-jo1
proximal muscle weaknes, elevated muscle enzymes(in skeletal, cardia, brain, CPK), elevated myoglobin (in skeletal, higher affinity for o2 than HGb, high in O2 deprivation, skeletal damage> increase in blood to kidney>nephrotoxic>renal failure) |
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progressive systemic sclerosis
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Anti-Scl 70
viscerla organ fibrosis, facial tightening, sclerodactyly |
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sjogren's syndrome
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Anti-SSa (anti-ro), Anti-SSb (anti-LA)
Xerostomia (drymouth>carries, infections), keratoconjuctivitis sicca (corneal ulcers, or erosions), arthritis. |
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Idiopathic thrombocytopenic purpura
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Anti-structural platelets
thrombocytopenia, petechiae&purpura, mucosal bldg |
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Vitiligo
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Anti-melanocyte
hypopigmented areas of skin, white hair in area of affected skin, sunburn risk |
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rheumatoid arthritis
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4/7 criteria must be present
morning stiffness>1hr arthritis in 3 or more joints simultaneously arhtritis in hand joints symmetrical arthritis rheumatoid nodules(on extension surface or arm and dorsum of hand) serum rheumatoid factor (Anti-IgG) erosion or bony decalcification identifiable on Xray |
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systemic Lupus erythematosus
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M: malar rash
D: Discoid Rash S: serositis O: oral ulcers A: arthritis P: photosensitive B: blood cells R: raynauds A: ANA, I: immunologic: Anti-DsDNA, Anti-smith N: Nephropathy Lupus( wire loops) |
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Drug induced Lupus
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Anti-Histone
Arthralgia, Fever, Serositis most commonly: hydralazine, procainamide |
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Crest: focal sclerosis
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Anti-centromere
C: calcinosis R: raynauds E: esophageal dysmotility(dysphagia for both solids and liquids because decrease peristalsis) S: Sclerodactyly T: telangiectasia (dysphagia only for solids: antaomical obstruction) |
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Mysthenia Gravis
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Anti-Ach receptor
post-use episodi muscle weakness, ptosis (usually first sign), thymus gland pathologies. worst in the evening |
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Graves diz
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Anti-TSH receptor (antibody sit in the active site and activate thyroid gland)
symptomatic hyperthroidism, exophthalmos, pretibial myxedema (non-pitting edema, specific for graves). |
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Hashimoto's thyroiditis
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Anti-microsomal (anti thyroid peroxidase, anti thyroglobulin)
nontender goiter, typically female, hypothyroidism (becomes symptomatic) |
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Wegners granulomatosis (caps are inflamed)
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anti-neutrophil cytoplasm (ANCA)
sinusitis, glomerulonephritis, lung lesions (cavitary) |
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celiac sprue
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Anti gliadin (wheat, rye, barley, oats)
Malabsorption ( often wiht diarrhea), dermatitis herpetiformis, short stature destruction of villi |
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Goodpasture's syndrome
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Anti-glomerular basement membrane (antigbm)
severe glomerulonephritis, pulmonary hemorrhage, dyspnea |
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primary biliary cirrhosis
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Anti-mitochondrial
puritis (usually first sign due to accumulation of bile acids in skin), female, jaundice |
