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18 Cards in this Set
- Front
- Back
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type of hormone that GnRH is
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peptide
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where GnRH neurons are born
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vomeronasal organ
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where GnRH neurons migrate to
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hypothalamus
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how GnRH secretion is regulated
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negative feedback
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where GnRH is released into
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hypophysioportal blood system
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the function of GnRH
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stimulates anterior pituitary gonadotrophs to synthesise and secrete gonadotrophins LH and FSH
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Mammalian GnRH receptors
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don't have a C-terminal tail so they don't densensitise rapidly
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Non-mammalian GnRH receptors
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have a C-terminal tail so desensitize rapidly
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how big is GNRH?
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relatively small - decapeptide so 10 amino acids
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What is Kallman's syndrome?
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GNRH doesn't migrate to hypothalamus resulting in anosmia,hyopgonadal hypogonadism and syntaxia
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how is GnRH secreted?
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in a pulsatile manner
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approximately how many GnRH neurons are there in the hypothalamus?
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1000
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what type of receptor does GnRH act via?
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Type 1 GnRh-R in the pituitary
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What does GnRH increase?
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Calicum ions, phopholipase C, inositol triphosphate and protein kinase C
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Which G protein is involved in GnRH-signalling?
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G-aq/11
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Why are calcium ions important in the signalling?
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important for the release of LH and FSH regualted exocytosis
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why is receptor densensitisation important?
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don't want constant stimulation - otherwise causes downregulation of receptors
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Why is it important that mammalian GnRH receptors do not desensitise rapidly?
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need to be ready to react to the pulsatile stimulation
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