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23 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What receptors are in the Gq protein class
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H1, α1, V1, M1, M3
(HAVe 1 M&M) |
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What receptors are in the Gi protein Class
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M2, α2, D2
(MAD 2's) |
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What receptors are in the Gs protein class
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ß1, ß2, D1, H2, V2
All the others not Gq or Gi |
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What drug can prevent Choline uptake into nerves
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Hemicholinium
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Drug prevents Choline Acetyltransferase (ChAT) uptake into vesicles
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Vesamicol
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Chemical prevents release of ACh from vesicles into synapse
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Botulinum
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Prevents tyrosine ---->DOPA
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Metyrosine
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Prevents dopamine uptake into vesicles
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Reserpine
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Prevents release of NE from vesicles into synapse
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Guanethidine
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Prevents NE reuptake from Synapse
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Cocaine and TCA
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Increases release of NE into synapse
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Normally Ca++
Amphetamines increase this |
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What modulates NE release from Sympathetic nerve endings
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ACh acting on M2 receptor Decreases NE release
NE --->α2 decreases NE release via neg. feedback Angiotensin II increases NE release |
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Bethanechol MOA and Uses
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Muscarinic Agonist (resistant to AChE)
Postop and neurogenic Ileus and urinary retention. |
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Pilocarpine MOA and Uses
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Muscarinic Agonist (resistant to AChE)
Potent stimulator of Sweat, tears, saliva.--Glaucoma (topical), xerostomia |
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Methacholine MOA and Uses
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Muscarinic Agonist
Stims M receptors in Airway when inhaled--Methacholine Challenge |
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Edrophonium MOA and uses
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AChE inhibitors--> inc. ACh in synapse
DX---Myasthenia Gravis; also used to diff MG from cholinergic Crisis |
Kaplan pharm 48
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Physostigmine MOA and Uses
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AChE inhibitors--> inc. ACh in synapse
(crosses BBB) ANTIDOTE for atropine OD, also used for Glaucoma |
fire down below
Kaplan pharm 48 Physo versus Pyridostigmine |
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Antidote for Atropine
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Physostigmine
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Donepezil MOA and Uses
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AChE inhibitors--> inc. ACh in synapse
Tx of Alzheimer dz |
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Tacrine MOA and Uses
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AChE inhibitors--> inc. ACh in synapse
Tx of Alzheimer dz |
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How do Organophosphates work and name some Chemicals
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Irreversibly inhibit AChE
Parathion, Malathion (insecticides) Sarin nerve gas |
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What is the cause of death with organophosphate poisoning
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Permanent depol of diaphragm prohibits breathing
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Management of Organophosphate poisoning
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Atropine for Muscarinic effects
Pralidoxime (2-PAM) to regen AChE 2-PAM is time dependent as over time the fxnal group it binds to is gone. |
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