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51 Cards in this Set

  • Front
  • Back
in the vas sm muscle which ions move in w/ depolarization
Na

Cl

Ca
which ions move out in the vas sm muscle w/ depolar.
K
what's the potential inside the cell
- 50-70 mVolts
what maintains the membrane potential of the vas sm muscle
Na-K Atpase
why's it neg inside the cells
cuz 3 Na's go inside while only 2 K's come out
t/f

a1 adrenergic antag are 1 st line agents in HTN
f

although they're very effective they have too many SE due to many receptors in the body
there's ------ blockade of vascular a1 adrenergic receptors
reversible
what do a1 adrenergic antag do to the vascular tone
decreases it
what do a1 adrenergic antag do to tpr
reduction
there's constriction/dilation of precapillary arterioles
dilation
how's there a reflex increase in hr w/ a1 adrenergic antag
the baroreflex is activated due to lower bp

this will activate the sns release of ne in the heart to act on B1 receptors

this will lead to tachycardia

a1 not there to counteract
prazosin selective for ----
alpha 1
theres evidence of mild reduction in ---- and ---- and increased ----
reduction in LDL

reduction in TG

increased HDL
what's prazosin used in combo w/
BB

diuretics
doesing of prazosin:
2-3/day

noncompliance

short t1/2
t/f

prazosin diffrentiates btw alpha 1 subtypes
f

no differentiation
what does prazosin block
sm muslce and prevent contraction
se of prazosin include:

orthostatic hypotension. . . why
block vascular sm muscle
se of prazosin can lead to postural -------
dizziness
postural dizziness can occur w/ a ---, -----, --- --- --
HA

Drowsiness

Lack of Energy
prazosin may have --- reflex tachycardia
mild
why have mild reflex tachycardia w/ prazosin
may be dut to central sympatholytic activity

vasodilate both arteries and veins

a1 mediated chronotripic effects
prazosin will have increased --- leading to increase ang 2
renin
why give a diuretic w/ prazosin
due to increase Na and H2O retention
why give a bb w/ prazosin
due to mild reflex tachycardia
in men prazosin can lead to
impotence

a1 antagonist can interfere w/ ejaculation
which diuretic is usu given w/ prazosin
thiazide

cuz it will also vasodilate
why have an increased Na and H2O in prazosin
due to elevated aldosterone
what can attenuate the response of prazosin
NSAIDs

cuz they affect prostaglandins
what can enhance the post hypotension w/ prazosin
bb
caution w/ prazosin in what two disease
cardiac and renal failure
two other selective a1 agents
terazosin

doxazosin
which is more frequently used terazosin or doxazosin

why
doxazosin

cuz 1x day dosing
dosing fo terazosin
1-2 x day
a1 selective agents can be used for
bph
how do the other a1 selective agents help w/ bph
relax prostate, bladder and head of urethra, which will increase urine flow
other a 1 antag will --- insulin resistance
decrease
doxazosin can --- incidence of -----
incease

CHF

according to ALLHAT
which has a longer t 1/2 and once daily dosing prozosin or the others
others
two a1 antag that are available in europe
ketanserin

urapadil
ketanserin will block what receptors
5HT2a

5HT2c

a1
urapadil will block what receptors
a1

a2

5HT1a
why does tamsulosin have limited effects on vasculature
cuz it a1a selective

the vasculature has a1b receptors
se of tamulosin
hypotension

dizziness
tamulosin used for ----
bph
mixed antagonist
labetalol

carvedilol
labetalol is a b blocker w/ --- at B- receptors
ISA

B2
carvedilol is a bb, ---- antagonsit
a1 antagonist
which has no isa
carvedilol
which has membrane stabilizing activity
carvedilol
what is labetalol better in:

beta blocking or a1 antagonising
beta blocking

but the a antagonist targets htn at the vessels and the heart. . . good!