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77 Cards in this Set
- Front
- Back
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products of ----
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streptomyces
too toxic to use as abx |
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daunorubicin, doxorubicin, idarubicin
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hematological and solid tumors
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bleomycin:
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testicular
head neck cervical hodgkin's lymphoma and sarcomas |
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dactinomycin tx
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ewings sarcoma
wilm's tumor |
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plicamycin
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testicular
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plicamycin tx
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testicular ca
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mitomycin tx
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stomach
pancreas lung |
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moa of abx's
directly bind to ---- or -- btw dna bps preventing dna ----- |
dna
intercalate replicaton |
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dactinomycin
--- dna -- strand breaks |
intercalates
single |
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t/f
dactinomycin is cell specific |
f
not cell specific |
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dactinomycin
one of the ---- tumor agents |
potent
also one of the most toxic |
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dactinomycin used for
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rhabdomyosarcoma
wilm's tumor in kids |
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tox of dactinomycin
---penia ---ia --- ----- ---cia --- effects |
pancytopenia
anorexia n/v alopecia gi effects |
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how do daurubicin and doxorubicin differ
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by OH group
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daurubicin and doxorubicin
intercalate into dna prevent ------ inhibits ------ |
prevents uncoiling
inhibits topoisomerase 2 (repairs strand breaks) |
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preventing topoisomerase will prevent
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uncoiling of dna for copying
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daurubicin and doxorubicin
bind to cell ----- alters --- activation |
membrane
IP3 |
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daurubicin and doxorubicin
may be --- toxic |
cardiotoxic
lifelimit on both meds |
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daurubicin and doxorubicin originally obtained from
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stretococcus peucetius caesius
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daurubicin and doxorubicin
metabolism forms --- ---- which forms --- ---- |
semiquinone intermediate
free radicals |
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daurubicin and doxorubicin
interacts w/ dna to cause ---- --- and --- ---- |
dna damage
strand breaks |
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daurubicin and doxorubicin
inhibit dna ----- and ---- -- |
polymerase
topoisomerase 2 |
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what enzyme scavengers free radicals
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superoxide dismutase . .. so a deficiency will lead to more free radicals
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what tissues are low in superoxide dismutase
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tumors
cardiac tissue |
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what combines two free radicals to creaste H2O2 and catalase
converts H2O2 to H2O |
superoxide catalase
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what tissue is low in superoxide catalase
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cardiac tissue
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daurubicin and doxorubicin forms free radicals
cardiac tissue low in superoxide dismutase and catalase what can occur |
cardiotoxicity
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daurubicin and doxorubicin route
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I
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t/f
daurubicin and doxorubicin cell specific |
f
not cell specific |
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daurubicin used to tx
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acute myelogenous leukemia
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danoxome liposomal prep used to tx
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kaposi sarcoma
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which has a wider use
daurubicin or doxorubicin |
doxorubicin:
breast bladder lung ovarian testicular thyroid all hodgkin nonhodgkin sarcoma neuroblastoma |
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tox of daurubicin and doxorubicin
moderate --- --- ---supprssion --- tox discoloration of ------ |
n/v
myelosuppression cardiac toxicity discoloration of urine |
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daurubicin and doxorubicin
cardiac toxicity: r/t |
cumulative dose
myocardial cell damage heart failure |
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daurubicin and doxorubicin
what is used as a chelator and prevents free radicals |
dexrazoxane-Fe
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--- complexes not taken up into heart cells
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lipid
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what color does urine turn w/ daurubicin and doxorubicin
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red
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daurubicin and doxorubicin tox
---- ulcerations -- disturbances ---cia severe --- properties severe --- and ---- of tissue |
mucosal
gi disturbances alopecia severe vesicant properties severe ulcerations and necrosis of tissue |
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daurubicin and doxorubicin tox
--- leukemias ---genic |
secondary leukemias
teratogenic |
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doxorubicin = -----
part of the --- regimen for hodgkin's |
adramycin
ABVD |
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idarubicin, epirubicin, valrubicin are non cell specific/ cell specific
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non cell specific
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idarubicin used to tx
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aml
all cml |
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idarubicin is
more/less cardiotoxic more/less mucosititis |
less cardiotoxic
more mucosititis |
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daurubicin and doxorubicin
discolors the urine ___ |
red
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daurubicin and doxorubicin
---genic |
teratogenic
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epirubicin used to tx
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bladder
head neck breast lung ovarian severe n/v |
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epirubicin can cause --- toxicity
---genic |
cardiotoxicity
teratogenic |
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t/f
epirubicin will discolor urine red |
t
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valrubicin used to tx
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bladder tumors
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se of valrubicin
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red urine
teratogenic |
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mitoxantrone used to tx:
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aml
cll breast ovarian |
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mitoxantrone more/less cardiotoxic
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less
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mitoxantrone causes ---- -----
----cia --- toxicity --- dysfunction |
bone marrow suppression
alopecia hepatic toxicity sexual dysfunction |
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color of mitoxantrone injection
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blue
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mitoxantrone discolors urine:
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blue-green
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mitoxantrone nail color
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blue
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t/f
mitoxantrone has the same vesicant properties |
f
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mitoxantrone also used in progressive, relapsing, ---
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MS
multiple sclerosis |
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bleomycin from the
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stretpmyces verticillus
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bleomycin is a mixture of -- and ---
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A2
B2 |
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bleomycin
-- ring structure can --- w/ dna |
flat
intercalate |
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bleomycin
metal binding core complexes w/ -- and --- |
Fe
Cu (stimulate free radical formation) |
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bleomycin
in presence of O2 metal complexes produces --- ---- breaks DNA, --- ----- |
free radicals
lipid peroxidation |
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bleomycin
cell specific? |
yes
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bleomycin
specific for -- phase |
G2
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bleomycin used to tx
|
cervical
head/neck pancreatic testicular ovarian hodgkin's nonhodgkin's sarcoma bladder |
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bleomycin
part of the -- regimen |
ABVD
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ABVD regimne
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adriamycin
bleomycin vinblastin darcarbazine |
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tox of bleomycin
low ----- ---genic dry ----- can lead to --- ----- |
low myelosuppression
teratogenic dry cough pulmonay fibrosis |
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bleomycin tox
--- and ---- mild -- and ---- ---ia |
fever and chills
n/v alopecia |
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bleomycin tox
---- ulceration ---rxns hyper------ --- of skin |
mucosal
skin rxns hyperpigmentation blistering of skin |
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mitomycin from
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streptomyces casepitosis
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mitomycin
---tion forms ----- ---- --- breaks |
alkylation
free radicals chromosal breaks |
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mitomycin
soln color |
blue-grey
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mitomycin txs
|
head/neck
breast colon soft tissue sarcoma mestatic bone stomach lung bladder |
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mitomycin tox:
cumulative severe --- ---- wait -- weeks btw txs |
bone marrow suppression
wait 8 weeks |
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mitomycin tox
-- tox ---ia secondary ------ |
pulmonary toxicities
alopecia secondary leukemia's |
