• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/19

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

19 Cards in this Set

  • Front
  • Back
What are Coagulopathies?
deficiencies in one or more components that regulate hemostasis.
What are deficiencies in one or more components that regulate hemostasis?
Coagulopathies
What is immune thrombocytopenic purpura (ITP)?
autoimmune destruction of platelets
What is Thrombotic Thrombocytopenic Purpura (TTP)?
rare disorder where platelets clump together inappropriately
immune thrombocytopenic purpura ITP symptoms?
-large bruises
-petichial rashes
-bleeding gums
-intracranial bleed
-splenic sequestration (spleen holds 90% of cells vs. 30%)
thrombotic thrombocytopenic purpura (TTP) symptoms?
-thrombocytopenia
-anemia
-purpura (red/purple patches)
-renal failure
What goes wrong with immune thrombocytopenic purpura (ITP)?
normal # of platelets are made. IgG is made that directs toward platelets. the coating on platelets make them more susceptible. spleen attacks and lyses the platelets.
What goes wrong with thrombotic thrombocytopenic purpura (TTP) symptoms?
mechanism unknown. platelets clump together which keeps them out of the normal circulation. platelets are unable to respond to injury.
What is Disseminated Intravascular Coagulation (DIC)?
clotting/bleeding happen simultaneously
What are some causes of Disseminated Intravascular Coagulation (DIC)?
-gram negative sepsis
-hypoxia
-acidosis
-cardiopulmonary arrest
-burns
-complications of pregnancy
-malignancy
Clinical features of Disseminated Intravascular Coagulation (DIC):
-sudden onset of bleeding (every orifice)
-thrombi causes multiple infarcts
-increased PT/PTT
-increased fibrin degradation products (FDP)
What do increased Prothrombin time (PT)/Partial thromboplastin time (PTT) levels tell us with DIC?
it will take longer for pt. blood to clot
PT/PTT test what?
pt. ability to clot
PPT test?
assesses intrinsic pathway
PT test?
assesses extrinsic pathway
What do increased FDP levels tell us with Disseminated Intravascular Coagulation (DIC)?
there is increased fibrinolysis
Hemophilia A, B (Christmas disease):
Hemophilia A: classic hemophilia. typically missing clotting factor VIII.
Hemophilia B: missing clotting factor IX
Who shows the trait for the Hemophilias?
X linked clotting disorder. only affecting males. women can be carriers
Why do these patients bleed with Hemophilias?
platelet plugs cannot form, inhibiting clotting. affects the intrinsic pathway