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75 Cards in this Set

  • Front
  • Back
Tissue factor activates factor ______ to begin the extrinsic pathway.
VII
Tissue factor activates factor VII to begin the ______ pathway.
extrinsic
Extrinsic and intrinsic pathways unite at the ______.
common pathway
Common pathway creates______.
thrombin
Thrombin converts fibrinogen into ______ fibers.
insoluble fibrin fibers
Thrombin converts ______ into insoluble fibrin fibers.
fibrinogen
T______ converts fibrinogen into insoluble fibrin fibers.
Thrombin
Insoluble fibrin fibers become part of the ______.
clot
More than a simple cascade, coagulation is a n______.
network
The end result of coagulation is?
conversion of fibrinogen into fibrin
Fibers weave thru platelet plug and trap ______within the mesh.
RBCs
Active factor XIII converts f______ into a cross-linked polymer that stabilizes the clot.
fibrin
Active factor XIII converts fibrin into a ______ polymer that stabilizes the clot
cross-linked
Active factor XIII converts fibrin into a cross-linked polymer that ______ the clot
stabilizes
Ac______ converts fibrin into a cross-linked polymer that stabilizes the clot
Active factor XIII
as clot forms it incorporates ______molecules.
plasmin
Plasmin is the _____ of its own distruction.
seeds
Plasmin is an enzyme created from ______ by thrombin and tissue plasminogen activator (t-PA).
plasminogen
Plasmin is an enzyme created from plasminogen by ______ and tissue plasminogen activator (t-PA).
thrombin
Plasmin is an enzyme created from plasminogen by thrombin and ______.
tissue plasminogen activator (t-PA).
______ is an enzyme created from plasminogen by thrombin and tissue plasminogen activator (t-PA).
Plasmin
Plasmin breaks down ______ polymers into fibrin fragments.
fibrin
Plasmin breaks down fibrin polymers into fibrin ______.
fragments
Define fibrinolysis.
The dissolution of fibrin by plasmin.
As the damaged blood vessels repairs, fibrinolysis helps remove the ______.
clot
Source of collagen.
subendothelial extracellular matrix
Collagen is actived by or released in response to:
injury exposes collagen to plasma clotting factors
Collagen role in coagulation.
Starts intrinsic pathway
von Willebrand factor source.
endothelium, megakaryocytes
von Willebrand factor is actived by or released in response to:
exposure to collagen
von Willebrand factor role in coagulation:
regulates level of factor VIII
Dificiency or defect of vWF causes:
prolonged bleeding
Kininogen and kallikrein source:
Liver and plasma
Kininogen and kallikrein act'd by or released by:
Cofactors normally present in plasma pathway
Kininogen and kallikrein role in coagulation
Cofactors for contact activation of intrinsic pathway.
Kininogen and kallikrein mediate i______ and enhance fibrinolysis.
inflammatory response
Kininogen and kallikrein mediate inflammatory response and enhance ______.
fibrinolysis
Tissue factor aka:
factor III
tissue thromboplastin
Source of TF
most cells except platelets
TF act'd by or released by:
tissue damage
TF role in coagulation
starts extrinsic pathway
prothombin and thrombin aka
factor II
prothombin and thrombin source
platelet lipids
Ca ion
factor V
prothombin and thrombin role in coagulation
fibrin production
Fibrinogen and fibrin aka
factor I
Fibrinogen and fibrin source
Liver and plasma
Fibrinogen and fibrin act'd or released in response to
thrombin
Fibrinogen and fibrin
forms insol fibers that stabilize platelet plug
Fibrin-stabilizing factor aka
factor XIII
factor XIII aka
Fibrin-stabilizing factor
Fibrin-stabilizing factor source
Liver, megakaryocyte
Fibrin-stabilizing factor act'd by or released by
platelets
Fibrin-stabilizing factor role in coagulation
cross-lnks fibrin polymers to make stable mesh
Ca ion aka
factor IV
factor IV aka
Ca ion
Ca ion source
Plasma ions
Ca ion role in coagulation
required for several steps of coagulation cascade
Ca ion (is/is never) a limiting factor
is never
vitamin K source
diet
Vit K role in coagulation
needed for synthesis of factors:
II
VII
IX
X
plasminogen and plasmin sources
Liver
Plasma
plasminogen and plasmin act'd by or released by
t-PF
thrombin
plasminogen and plasmin role in anticoagulation or fibrinolysis
dissolves fibrin and fibrinogen
Tissue plasminogen activator aka
t-PA
Tissue plasminogen activator soure
many tissues
Tissue plasminogen activator activated by or released by:
normally present
levels increase with stress and protein C
Tissue plasminogen activator role in anticoagulation or finrinolysis
actives plasminogen
Tissue plasminogen activator used clinically to_______
dissolves clots
Antithrombin III sources
Liver and plasma
Antithrombin III role in anticoagulation or fibrinolysis
anticoagulant
Antithrombin III blocks
Factors
IX
X
XI
XII
also thrombin and kallikrein
Antithrombin III facilitated by ______
heparin
antithrombin (has/has no) effect on thrombin
has no
Prostacyclin (prostaglandin) I or PGI2 source
endothelial cells
Prostacyclin (prostaglandin) I or PGI2 role in anticoagulation or fibrinolysis
blocks platelet aggregation
vasodilator