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75 Cards in this Set
- Front
- Back
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Tissue factor activates factor ______ to begin the extrinsic pathway.
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VII
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Tissue factor activates factor VII to begin the ______ pathway.
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extrinsic
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Extrinsic and intrinsic pathways unite at the ______.
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common pathway
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Common pathway creates______.
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thrombin
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Thrombin converts fibrinogen into ______ fibers.
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insoluble fibrin fibers
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Thrombin converts ______ into insoluble fibrin fibers.
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fibrinogen
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T______ converts fibrinogen into insoluble fibrin fibers.
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Thrombin
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Insoluble fibrin fibers become part of the ______.
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clot
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More than a simple cascade, coagulation is a n______.
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network
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The end result of coagulation is?
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conversion of fibrinogen into fibrin
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Fibers weave thru platelet plug and trap ______within the mesh.
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RBCs
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Active factor XIII converts f______ into a cross-linked polymer that stabilizes the clot.
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fibrin
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Active factor XIII converts fibrin into a ______ polymer that stabilizes the clot
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cross-linked
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Active factor XIII converts fibrin into a cross-linked polymer that ______ the clot
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stabilizes
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Ac______ converts fibrin into a cross-linked polymer that stabilizes the clot
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Active factor XIII
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as clot forms it incorporates ______molecules.
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plasmin
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Plasmin is the _____ of its own distruction.
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seeds
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Plasmin is an enzyme created from ______ by thrombin and tissue plasminogen activator (t-PA).
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plasminogen
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Plasmin is an enzyme created from plasminogen by ______ and tissue plasminogen activator (t-PA).
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thrombin
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Plasmin is an enzyme created from plasminogen by thrombin and ______.
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tissue plasminogen activator (t-PA).
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______ is an enzyme created from plasminogen by thrombin and tissue plasminogen activator (t-PA).
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Plasmin
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Plasmin breaks down ______ polymers into fibrin fragments.
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fibrin
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Plasmin breaks down fibrin polymers into fibrin ______.
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fragments
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Define fibrinolysis.
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The dissolution of fibrin by plasmin.
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As the damaged blood vessels repairs, fibrinolysis helps remove the ______.
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clot
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Source of collagen.
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subendothelial extracellular matrix
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Collagen is actived by or released in response to:
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injury exposes collagen to plasma clotting factors
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Collagen role in coagulation.
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Starts intrinsic pathway
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von Willebrand factor source.
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endothelium, megakaryocytes
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von Willebrand factor is actived by or released in response to:
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exposure to collagen
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von Willebrand factor role in coagulation:
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regulates level of factor VIII
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Dificiency or defect of vWF causes:
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prolonged bleeding
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Kininogen and kallikrein source:
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Liver and plasma
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Kininogen and kallikrein act'd by or released by:
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Cofactors normally present in plasma pathway
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Kininogen and kallikrein role in coagulation
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Cofactors for contact activation of intrinsic pathway.
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Kininogen and kallikrein mediate i______ and enhance fibrinolysis.
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inflammatory response
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Kininogen and kallikrein mediate inflammatory response and enhance ______.
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fibrinolysis
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Tissue factor aka:
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factor III
tissue thromboplastin |
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Source of TF
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most cells except platelets
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TF act'd by or released by:
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tissue damage
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TF role in coagulation
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starts extrinsic pathway
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prothombin and thrombin aka
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factor II
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prothombin and thrombin source
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platelet lipids
Ca ion factor V |
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prothombin and thrombin role in coagulation
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fibrin production
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Fibrinogen and fibrin aka
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factor I
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Fibrinogen and fibrin source
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Liver and plasma
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Fibrinogen and fibrin act'd or released in response to
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thrombin
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Fibrinogen and fibrin
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forms insol fibers that stabilize platelet plug
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Fibrin-stabilizing factor aka
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factor XIII
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factor XIII aka
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Fibrin-stabilizing factor
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Fibrin-stabilizing factor source
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Liver, megakaryocyte
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Fibrin-stabilizing factor act'd by or released by
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platelets
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Fibrin-stabilizing factor role in coagulation
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cross-lnks fibrin polymers to make stable mesh
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Ca ion aka
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factor IV
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factor IV aka
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Ca ion
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Ca ion source
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Plasma ions
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Ca ion role in coagulation
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required for several steps of coagulation cascade
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Ca ion (is/is never) a limiting factor
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is never
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vitamin K source
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diet
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Vit K role in coagulation
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needed for synthesis of factors:
II VII IX X |
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plasminogen and plasmin sources
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Liver
Plasma |
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plasminogen and plasmin act'd by or released by
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t-PF
thrombin |
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plasminogen and plasmin role in anticoagulation or fibrinolysis
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dissolves fibrin and fibrinogen
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Tissue plasminogen activator aka
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t-PA
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Tissue plasminogen activator soure
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many tissues
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Tissue plasminogen activator activated by or released by:
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normally present
levels increase with stress and protein C |
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Tissue plasminogen activator role in anticoagulation or finrinolysis
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actives plasminogen
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Tissue plasminogen activator used clinically to_______
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dissolves clots
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Antithrombin III sources
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Liver and plasma
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Antithrombin III role in anticoagulation or fibrinolysis
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anticoagulant
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Antithrombin III blocks
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Factors
IX X XI XII also thrombin and kallikrein |
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Antithrombin III facilitated by ______
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heparin
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antithrombin (has/has no) effect on thrombin
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has no
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Prostacyclin (prostaglandin) I or PGI2 source
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endothelial cells
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Prostacyclin (prostaglandin) I or PGI2 role in anticoagulation or fibrinolysis
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blocks platelet aggregation
vasodilator |
