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16 Cards in this Set

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Heparin
acidic (protamine)
parenterally
LMW Heparin - enoxaparin have greater bioavailability and longer duration. SC
Fondaparinux
Heparin
mechanism of action
bind to AT3- the complex irreversibly bind and inactivate thrombin, F10...
LMW Heparin
mechanism of action
have the same action on AT3 and F10 but not on thrombin.
PTT test is not relavent
Heparin
clinical use
rapid action- given when needed immediatly.
DVT
Pulmonary embolism
MI
(DOES NOT CROUS THE PLACENTA)
Heparin
Toxicity
increased bleeding
moderate transient thrombocytopenia
* some patients may develop antibodies against heparin bound to platelet factor 4 = severe thrombocytopenia and thrombosis.
prolong use- osteoporesis
Direct thrombin inhibitors
Lepirudin
Bivalirudin
Argatroban הרגה טרובן
Direct thrombin inhibitors
mechanism of action
Lepirudin and Bivalirudine- bind simultaneously to the active site of thrombin and to thrombin substrates.
Argatroban- bind only to the thrombin.
They inhibit both soluble and enmeshed thrombin.
Coumarin anticoagulantes
Warfarin- small lipid soluble, orally administratef, cross the placenta. highly bound to albomin- eliminated by the cyt p450.
Coumarin anticoagulantes
mechanism of action
interfere with the posttranslational modification of clotting factors in the liver, a procedd that depends on vitamin K.
ANTIPLATELETS
ASPIRIN
PDE3 INHIBITORS
ANTAGONISTS OF ADP RECEPTORS
GLYCOPROTEIN RECEPTOR INHIBITORS
ASPIRIN
inhibits thromboxane synthesis by blocking the enzyme cyclooxygenase.
ANTAGONISTS OF ADP RECEPTORS
ticlopidine
clopidogrel
PDE3 INHIBITORS
dipyridamole
cilostazol
מתכון - קח את הדון פיריום והוסף קילו סטזול
GLYCOPROTEIN RECEPTOR INHIBITORS
abciximab - monoclonal antibody that reversibly inhibits the binding of fibrin to the glycoprotein receptor.
ticlopidine
toxicity
cause bleeding
TTP
THROMBOLITIC
alteplase
reteplase
tenecteplase
streptokinase
urokinase
anistreplase
ארט שואה art sua