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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
Heparin
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acidic (protamine)
parenterally LMW Heparin - enoxaparin have greater bioavailability and longer duration. SC Fondaparinux |
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Heparin
mechanism of action |
bind to AT3- the complex irreversibly bind and inactivate thrombin, F10...
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LMW Heparin
mechanism of action |
have the same action on AT3 and F10 but not on thrombin.
PTT test is not relavent |
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Heparin
clinical use |
rapid action- given when needed immediatly.
DVT Pulmonary embolism MI (DOES NOT CROUS THE PLACENTA) |
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Heparin
Toxicity |
increased bleeding
moderate transient thrombocytopenia * some patients may develop antibodies against heparin bound to platelet factor 4 = severe thrombocytopenia and thrombosis. prolong use- osteoporesis |
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Direct thrombin inhibitors
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Lepirudin
Bivalirudin Argatroban הרגה טרובן |
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Direct thrombin inhibitors
mechanism of action |
Lepirudin and Bivalirudine- bind simultaneously to the active site of thrombin and to thrombin substrates.
Argatroban- bind only to the thrombin. They inhibit both soluble and enmeshed thrombin. |
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Coumarin anticoagulantes
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Warfarin- small lipid soluble, orally administratef, cross the placenta. highly bound to albomin- eliminated by the cyt p450.
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Coumarin anticoagulantes
mechanism of action |
interfere with the posttranslational modification of clotting factors in the liver, a procedd that depends on vitamin K.
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ANTIPLATELETS
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ASPIRIN
PDE3 INHIBITORS ANTAGONISTS OF ADP RECEPTORS GLYCOPROTEIN RECEPTOR INHIBITORS |
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ASPIRIN
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inhibits thromboxane synthesis by blocking the enzyme cyclooxygenase.
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ANTAGONISTS OF ADP RECEPTORS
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ticlopidine
clopidogrel |
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PDE3 INHIBITORS
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dipyridamole
cilostazol |
מתכון - קח את הדון פיריום והוסף קילו סטזול
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GLYCOPROTEIN RECEPTOR INHIBITORS
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abciximab - monoclonal antibody that reversibly inhibits the binding of fibrin to the glycoprotein receptor.
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ticlopidine
toxicity |
cause bleeding
TTP |
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THROMBOLITIC
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alteplase
reteplase tenecteplase streptokinase urokinase anistreplase ארט שואה art sua |
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