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24 Cards in this Set
- Front
- Back
Factor XII
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Hageman Factor - binds to exposed collagen; Activated by HMWK and PK
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Factor XI
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PTA - activated by factor XIIa
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Factor IX
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Christmas Factor, PTC - activated by factor XIa in presence of Ca2+
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Factor VII
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Pronvertin SPCA - Activated by Thrombin in the presence of Ca2+; in tissue
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Factor X
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Stuart-Prower Factor - Activates on surface of platelets, VIIa, TF, Ca2+
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Factor II
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Prothrombin - Activated on surface of platelets, prothrombinase complex
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Factor VIII
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Antihemophilia factor a, AHG - activated by thrombin; factor VIIIa is cofactor for X by IX activation
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Factor III (TF)
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Tissue Factor - sub endothelial cell surface glycoprotein; cofactor for VII
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Factor I
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Fibrinogen - cleaved by thrombin to form fibrin clot
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Factor XIII
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Fibrin Stabilizer - Activated by thrombin in presence of Ca2+
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von Willebrand Factor
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associated with sub endothelial connective tissue; serves as bridge between platelets glycoprotein GbIb/IX and collagen
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Protein C
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Activated to Ca by thrombin bound to thrombomodulin; degrades factors VIIIa and Va
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Protein S
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Cofactor for protein C; both contain gla residues
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Thrombomodulin
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Protein on surface of endothelial cells; binds thrombin to activate protein C
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Antithrombin III
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Most important coagulation inhibitor; controls activities of IIa, factors IXa, Xa, XIa and XIIa
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Prekallikrein - PK
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Fletcher Factor
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High Molecular Weigh Kininogen - HMWK
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Contact activation factor
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Factor IV
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CALCIUM yo!!!
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Hemophilia A
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-Factor VIII
-X-linked w/ severe, mod, mild -150 mutations -1:5000, 1:10,000 males -joint and muscle hemorrhage -easy bruising & prolonged bleeding -treatment w/ VIII concentrates |
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Hemophilia B
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-Factor IX
-1/10 of A prevelance -X-linked w/ severe, mod, mild -300 mutations -85% point mutations -3% short nucleotide deletions or insertions -12% gross gene alterations |
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Disorders of Fibrinogen & Factor XIII
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-elevated levels in patients with CHD, hperlipidemias, diabetes and hypertension
-in pregnancy, menopause, women on oral contraceptives and smokers -other rare disorders show complete lack or deficiency -Afibringenemia: neonatal umbilical cord hemorrhage, mucosal hemorrhagen and recurrent abortion -Factor XIII - rare |
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von Willebrand Disease
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-most common
-due to inherited deficiency in vWF -most commonly inherited bleeding disorder -defective platelet adhesion (VIII) -heterogeneous disorder type 1, 2, and 3 -Autosomal dominant |
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Factor XI and Contact Adhesion
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-deficiency of Factor XI results in injury-related bleeding
-common in Ashkenazic jews -autosomal dominantL: three independent point mutations |
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Antithrombin Deficiency
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-Deficiency ranges from 1:2000 to 1:5000 in general pop
-deficiency arise from mutations that affect synthesis or stability and from mutations that affect protease and/or heparin binding sites -clinical consequences are deep vein thrombosis and pulmonary embolism -acute episodes and treated with heparin infusion |