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32 Cards in this Set
- Front
- Back
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PT monitors which pathway & which medicinal therapy?
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Extrinsic & Coumadin
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APTT monitors which pathway and which medicinal therapy?
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Intrinsic & Heparin
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What does a corrected APTT after a mixing study indicate?
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Factor deficiency
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What does a prolonged APTT after a mixing study indicate?
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A circulating anticoagulant(factor inhibitor)
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What is the normal PT & INR range?
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11-13 seconds; INR<2.0
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What is normal range for APTT?
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<35 seconds
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Which anticoagulant has an antithrombin effect?
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Heparin
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Which anticoagulant works as a vit K antagonist?
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Coumadin
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Which group requires vit K for synthesis & is affected by coumadin?
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Prothrombin group; 2,7,9,10
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What factors are in the intrinsic pathway?
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8,9,11,12 Prekallikrein (Fletcher factor) & High molecular weight kininogen HMWK (Fitzgerald factor)
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What factors are in the extrinsic pathway?
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3 & 7
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What factors are in the common pathway and what test is used to monitor them? (Test to monitor just the common pathway)
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1,2,5,10; Thrombin test
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What factors are consumed during clotting?
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1,2,5,8,13
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Hemophilia A is caused by a deficiency of what factor?
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8
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Hemophilia B is caused by a deficiency of what factor?
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9
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Another name for Hemophilia B is...?
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Christmas disease
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What factor is not measured by PT or APTT?
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13
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If the PT & APTT are both prolonged what does this mean?
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The factor deficiency is in the common pathway. (1,2,5,10)
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What are the PT & APTT test results in hemophilia A?
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PT-Normal; APTT-prolonged
(bleeding time and plt count are normal) |
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In what disease is the plt aggregation abnormal w/ristocetin?
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Von Willebrand's disease
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What are the three causes of a prolonged PT?
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Liver disease, coumarin therapy & factor 7 deficiency.
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What is the next step after getting a prolonged APTT (& normal TT)
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Mixing studies.
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What factor deficiency is seen with a prolonged PT & normal APTT?
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7
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What factor defiencies could be the cause of a normal PT and prolonged APTT?
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8,9,11,12
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What will happen the the test results (times) if the tube has less than the required 90% of blood?
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Increased times.
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`Avg. life span of a plt?
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9-12 days
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Why do coagulation studies need to be drawn in plastic tubes as opposed to glass?
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Plts adhere to glass tubes.
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The fibrinogen assay is a quantitative measure of factor __.
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1
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Askenazi jews have a high incidence of hemophilia ___.
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C (factor 11 deficiency)
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What disease is characterized by a plt adhesion defect & prolonged bleeding time?
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vWD
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What is the most common factor inhibitor?
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Factor 8 inhibitor.
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What is another name for secondary fibrinolysis?
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DIC
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