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26 Cards in this Set
- Front
- Back
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12 to 12a catalyzed by
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Activated platelets
Collagen |
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Platelet AAA
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Adhesion
activation Aggregation |
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vWF binds to what?
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GP1b Glyco protein 1 b on platelet binds to von Willebrand factore on sub endothelium.
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GP1a
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Glycoprotein 1 a binds platelet surface to sub endothelial layer. starts soft clotting
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GP1b
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binds vWF which is bound to endothelial layer
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Factor 7 activation describe
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VII finds tissue factor from extrinsic wound. Catalyzed to 7a
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7a > ?
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10 to 10a
9 to 9a to 10a |
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13a does what?
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Binds clot. only one not a serine protease
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TXA2 synthesis?
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Aracidontic acid from phospholipid bilayer catalyzed by cyclooxygenase (cox) cox 1
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TXA2 function?
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Vasoconstrictor
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von Willebrand/ Glycoproteins disorders
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Bruising/bleeding gums. low platelet adhesion to GP1a
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thrombocytopenia.
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Low platelets. Bruising, bleeding gums.
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Describe the effect of cyclooxygenase inhibitors
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Shut down TXA2 synthesis. no coagulation, no infalmmation. NSAIDS block Cox, aspirin, ibuproferin
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8A
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Cofactor with 9a makes 10 into 10a. binds both. intrinsic
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10a
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Catalyzes prothrombin to thrombin (2 to 2a)
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3
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Tissue factor (III) aka thromboplastin. Membrane protein that binds 7a and catalyzes 10 to 10a
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7a
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extrinsic signal protein. Catalyzes 10 to 10a when bound to tissue factor (3)
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13a
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binds fibrin in clot. catalyzed by thrombin (2)
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5a
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Cofactor of 10a. catalyized by thrombin
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1a
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Fibrin, from fibrinogen. made by thrombin (2a from prothrombin 2) Crosslinked by 13 to form clot
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11a
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Activates 9 to 9a
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9a
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with cofactor 8a activates 10 to 10a intrinsic
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12a
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Activates factor XI, VII and prekallikrein
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Explain the effect that inhibitors of gamma-carboxylation would have on coagulation
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Factor complexes couldn't form
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aPTT
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activated partial thromboplastin time (aPTT) test
intrinsic test |
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PT
what's it test? |
The tissue factor (extrinsic) pathway is initiated by release of tissue factor (a specific cellular lipoprotein), and can be measured by the prothrombin time (PT) test. extrinsic. monitors wayfarin
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