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27 Cards in this Set
- Front
- Back
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What is the MOA of CNS stimulants? |
1. Ampheatmines and methylphenidate promote release of NE and dopa at CNS synapses 2. Inhibit repute of NE and dopa |
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What are the two types of CNS stimulants? |
1. Methylphenidate (Ritalin) 2. Amphetamines |
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What is the MOA of amphetamines? |
1. Reverse DAT (dopamine transporter) 2. Reverses VMAT2 3. Elicits release of dopa and NE |
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What is the MOA of cocaine? |
1. Block monoamine reuptake |
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What is the effect of NE on the CNS? |
1. Alerting 2. Anorectic 3. Locomotor
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What is the effect of dopamine on the CNS? |
1. Behavioral effects (limbic) 2. Locomotor effects |
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What is the effect of high serotonin and high dopamine on the CNS? |
1. Disturbances of perception 2. Overt psychotic behavior |
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What are the CV effects of CNS stimulants? |
1. Increase BP 2. HR can be reflexly slowed 3. Arrhythmias |
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To what will tolerance develop with the use of CNS stimulants? |
1. Mood elevation 2. Appetite suppression 3. CV effects 4. Physical dependence |
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What dose of stimulants is used for ADHD? |
1. Low dose |
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What are the adverse effects of CNS stimulants? |
1. Insomnia 2. Growth/appetite suppression 3. HA 4. GI disturbance |
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What are the available durations of methylphenidate? |
1. Short, medium, and long |
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What are the dextroamphetamine drugs? |
1. Dexidrine-- short duration 2. Dexidrine spanules-- long duration |
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What is the MOA of atomoxitine? |
1. NE reuptake inhibitor
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What metabolizes atomoxitine? |
1. CYP2D6 |
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What is the clinical use of guanfacine? |
1. Once a day tx for pets 6-17 y/o with ADHD
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What is the MOA of guanfacine? |
1. Selective a-2A adrenergic agonist 2. Increase neurotransmission in prefrontal cortex |
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What are the adverse effects of guanfacine? |
1. Hypotension 2. Bradycardia 3. Syncope |
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What is the MOA of clonidine? |
1. a-2A agonist |
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What are the adverse effects of clonidine? |
1. Sedation 2. Hypotension |
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What is the indication for clonidine in ADHD? |
1. Monotx or adjunct with stimulants |
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What is the MOA of phentermine/topiramate in weight loss? |
1. Not known 2. Topiramate: blocks Na channels, increases GABA 3. Phentermine: stimulant |
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What is the indication for lorcaserin? |
1. BMI >30 2. BMI >27 in presence of at least one weight-related condition |
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What is the MOA of lorcaserin? |
1. Selective 5-HT2C receptor agonist |
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What are the adverse effects of lorcaserin? |
1. Serotonin syndrome |
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What is the MOA of modafinil? |
1. Unknown--- inhibits dopamine reuptake |
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What is the clinical use of modafinil? |
1. May inhibit activity of sleep promoting neurons in ventrolateral preoptic nucleus |
