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19 Cards in this Set
- Front
- Back
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Agents that have a stimulant effect primarily on autonomic centers involved in the regulation of respiration and circulation.
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Analeptics
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True or False
CNS stimulants generally possess low therapeutic indices. |
True
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An overdose of a CNS stimulant typically leads to ______________.
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Convulsions
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Reflex stimulants
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Lobeline
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Spinal Cord stimulant
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Strychnine
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Medullary stimulant
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Doxapram
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___________ alkaloids are classified as psychic stimulants.
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Xanthine
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True or False
Xanthines do not have diuretic properties. |
False
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True or False
Adenosine is involved in sleep. |
True
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True or False
Adenosine dilates blood vessels, and presynaptically excites release of excitatory CNTs. |
False
presynaptically inhibits. |
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There are 4 adenosine receptors.
A1 A2a A2b A3 Tell whether they are stimulatory or inhibitory. |
Inhibitory
Stimulatory Stimulatory Inhibitory |
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True or False
Classical xanthines are selective antagonists. |
False
Non-selective |
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A sympathomimetic agent that mimics the action of NE and dopamine. Classified as a psychic stimulant.
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Beta-phenethylamine
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What is the SAR of beta-phenylethylamine?
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1. Amine must be basic
2. Increase chain length, decrease activity. 3.Branching in chain at alpha is important. 4.Aromaticity is important for CNS activity. 5.Saturated alicyclics have peripheral activity. 6.Catechols and phenol lack CNS activity. 7. Beta-hydroxyl group decreases CNS activity but increases peripheral activity. |
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Cocaine has a very ______ onset of action and a _______ duration of action.
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Slow, Long
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What is the more active (+) threo isomer of methylphenidate?
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Dexmethylphenidate
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Is there treatment available for a crack addiction?
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No
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What can an orexin deficiency cause?
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Narcolepsy
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What is the R-isomer of modafanil approved in 2007 that inhibits dopamine transporters?
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Amodafanil
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