Cns Ii - Test 1 (Schizophrenia)

Front 1

Lowest potency FGAs?

Back 1

chlorpromazine

thioridazine

Front 2

Highest potency FGAs?

Back 2

fluphenazine

haloperidol

pimozide

Front 3

Haloperidol:

half-life?

metabolism?

Back 3

12 - 36 hrs

CYP 1A2, 2D6, 3A4

Front 4

Phenothiazines:

half-life?

metabolism?

high/low protein binding?

Back 4

8 - 35 hrs

CYP 3A4, 2D6

HIGHLY protein bound

Front 5

Half-life of loxapine?

Back 5

bi-phasic

initial 5 hrs

terminal 12-19 hrs

Front 6

Half-life of thiothixene?

Back 6

> 24 hrs (w/ chronic use)

Front 7

Low potency FGA AEs:

sedative effects? high/low

ACh effects? high/low

EPS? high/low

Hypotensive effects? high/low

Back 7

Low potency FGA AEs:

sedative effects? high

ACh effects? high

EPS? low

Hypotensive effects? high/

Front 8

High potency FGA AEs:

sedative effects? high/low

ACh effects? high/low

EPS? high/low

Hypotensive effects? high/low

Back 8

High potency FGA AEs:

sedative effects? low

ACh effects? low

EPS? high!

Hypotensive effects? low

Front 9

Movement disorder:

bizarre involuntary tonic contractions of skeletal muscles (mostly head & face)

Back 9

acute dystonic reaction: bizarre involuntary tonic contractions of skeletal muscles (mostly head & face)

Front 10

Movement Disorders:

strong feeling of inner restlessness

Back 10

akathisia: strong feeling of inner restlessness

Front 11

Movement Disorder rating scales: SAS

What does it stand for?

What does it rate?

Back 11

SAS (Simpson-Angus Scale)

Parkinsonism

Front 12

Movement Disorder Rating Scales:

Tardive dyskinesia?

Back 12

AIMS (abnormal involuntary movement scale)

&

DISCUS (dyskinesia identification system: condensed user scale)

Front 13

Movement Disorder Rating Scales: BARS

Stands for what?

Rates what?

Back 13

BARS (Barnes Akathisia Rating Scale)

Akathisia

Front 14

LAI Dosing: Fluphenazine

Starting Dose?

Target Dose?

Max Dose?

Dose interval?

PO overlap?

Back 14

LAI Dosing: Fluphenazine

Starting Dose? 12.5 - 25 mg

Target Dose? 12.5 - 50 mg

Max Dose? 100mg/dose

Dose interval? q 2-4 wks

PO overlap? recommmended

Front 15

LAI Dosing: Haloperidol

Starting Dose?

Target Dose?

Max Dose?

Dose interval?

PO overlap?

Back 15

LAI Dosing: Haloperidol

Starting Dose? 10-20x daily PO dose

Target Dose? 10-15x daily po dose

Max Dose? 100mg 1st dose; 450mg/mo

Dose interval? q 4 wks

PO overlap? recommended

Front 16

LAI Dosing: Risperidone

Starting Dose?

Target Dose?

Max Dose?

Dose interval?

PO overlap?

Back 16

LAI Dosing: Risperidone

Starting Dose? 25 mg + PO dose x 3 wks

Target Dose? 25-50 mg

Max Dose? 50mg

Dose interval? q 2 wks

PO overlap? required

Front 17

LAI Dosing: Paliperidone

Starting Dose?

Target Dose?

Max Dose?

Dose interval?

PO overlap?

Back 17

LAI Dosing: Paliperidone

Starting Dose? 234 mg then 156 mg day 8

Target Dose? 117 mg (39-234 mg)

Max Dose? 234 mg

Dose interval? q 4 wks

PO overlap? not required

Front 18

LAI Dosing: Olanzapine

Starting Dose?

Target Dose?

Max Dose?

Dose interval?

PO overlap?

Back 18

LAI Dosing: Olanzapine

Starting Dose? 150-300mg q2w or 405 q4w

Target Dose? 150-300mg q2w or 405 q4w

Max Dose? 300mg q2w or 405mg q4w

Dose interval? q 2 wks or q 4 wks

PO overlap? not required

Front 19

Brand Name for Paliperidone?

Back 19

Invega

Front 20

Brand Name for Olanzapine?

Back 20

Zyprexa

Front 21

Brand Name for Ziprasidone?

Back 21

Geodon

Front 22

Brand Name for Quetiapine?

Back 22

Seroquel

Front 23

Brand Name for Aripriprazole?

Back 23

Abilify

Front 24

SGA Dosing: Clozapine (Clozaril)

Dose Range?

Back 24

300-450 mg/day

Front 25

SGA Dosing: Risperidone (Risperdal)

Dose Range?

Back 25

2-6 mg/day

Front 26

SGA Dosing: Olanzapine (Zyprexa)

Dose Range?

Back 26

5-20 mg/day

Front 27

SGA Dosing: Quetiapine (Seroquel)

Dose Range?

Back 27

300-800 mg/day

Front 28

SGA Dosing: Ziprasidone (Geodon)

Dose Range?

Back 28

120-160 mg/day

Front 29

SGA Dosing: Aripiprazole (Abilify)

Dose Range?

Back 29

10-15 mg/day

Front 30

SGA Dosing: Palparidone (Invega)

Dose Range?

Back 30

6-12 mg/day

Front 31

SGA Dosing: Iloperidone (Fanapt)

Dose Range?

Back 31

12-24 mg/day

Front 32

SGA Dosing: Asenapine (Saphris)

Dose Range?

Back 32

5 mg BID

Front 33

SGA AEs:

highest risk for dose related EPS?

& increased prolactin?

(2 drugs)

Back 33

Risperidone

Paliperidone

Front 34

SGA AEs:

Drug most likely to cause
1) dose dependent lowering of seizure threshold
2) orthostatic hypotension

Back 34

clozapine

Front 35

SGA AEs:

3 drugs most likely to cause sedation?

Back 35

clozapine (Clozaril)

quetiapine (Seroquel)

olanzapine (Zyprexa)

Front 36

SGA AEs:

2 drugs most likely to cause weight gain?

Back 36

clozapine (Clozaril)

olanzapine (Zyprexa)

Front 37

SGA AEs:

3 drugs most likely to cause
1) lipid abnormalities
2) glucose intolerance

Back 37

clozapine (Clozaril)

olanzapine (Zyprexa)

quetiapine (Seroquel)

Front 38

ADA montoring recommendations for the use of antipsychotics & DM

Blood pressure & Fasting glucose should be measured when?

Back 38

baseline, 12 wks, then annually

Front 39

ADA montoring recommendations for the use of antipsychotics & DM

Fasting lipids should be measured when?

Back 39

baseline, 12 wks, then q 5 yrs

Front 40

ADA montoring recommendations for the use of antipsychotics & DM

Waste circumference should be measured when?

Back 40

baseline, then annually

Front 41

ADA montoring recommendations for the use of antipsychotics & DM

Weight (BMI) should be measured when?

Back 41

baseline, 4 wks, 8 wks, 12 wks, quarterly, & annually

Front 42

SGA metabolism

clozapine & olanzapine?

Back 42

1A2 (major)

Front 43

SGA metabolism:

Risperidone & Aripiprazole?

Back 43

2D6 (major)

Front 44

SGA metabolism:

Quetiapine (Seroquel)?

Back 44

3A4 (major)

Front 45

SGA metabolism:

Ziprasidone?

Back 45

2/3 aldehyde oxidase

1/3 3A4

Front 46

Clozapine montoring:

every ___ for ___

then every ___ for ___

then every ___

Back 46

every week for 6 mo

then every 2 weeks for 6 mo

then every 4 wks