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16 Cards in this Set
- Front
- Back
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___ is characterized by as loss of, or decline in memory & other cognitive abilities.
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*Dementia* is characterized by as loss of, or decline in memory & other cognitive abilities.
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Term for "decline in memory"
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amnesia: decline in memory
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Term for "ability to generate coherent speech or understand spoken or written language"
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aphasia: ability to generate coherent speech or understand spoken or written language
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Term for "ability to recognize or identify objects, assuming intact sensory function"
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agnosia: ability to recognize or identify objects, assuming intact sensory function
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Term for "ability to execute motor activites, assuming intact motor abilities"
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apraxia: ability to execute motor activites, assuming intact motor abilities
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Term for "ability to think abstactly, make sound judgements, & plan & carry out complet tasks"
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executive functioning: ability to think abstactly, make sound judgements, & plan & carry out complet tasks
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Reversible causes of dementia?
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Reversible causes of dementia:
- B12 deficiency - hypothyroidism |
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Life expectancy (range) after onset of AD symptoms?
Average? |
Life expectancy (range after onset of AD symptoms? 3-20 years
Average? 8 years |
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Mutations in early-onset, familial AD?
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Mutations in early-onset, familial AD:
- Chromosome 1: presenilin 1 - Chromosome 14: presenilin 2 - Chromosome 21: Amyloid Precursor Protein (APP) |
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Mutations in late-onset AD?
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Mutations in late-onset AD?
- ApoE: Chromosome 19 (3 alleles) |
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Abnormal processing of Amyloid Precursor Protein (APP) involves cleavage by ___ then ___.
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Abnormal processing of Amyloid Precursor Protein (APP) involves cleavage by *beta-secretase* then *gamma-secretase*.
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Neurofibrillary tangles (NFT) are found especially in which 2 parts of the brain?
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Neurofibrillary tangles (NFT) are found especially in *hippocampus & cerebral cortex*
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Mini Mental Status Exam tests on which 5 areas of cognition?
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Mini Mental Status Exam tests on 5 areas of cognition:
- orientation - registration - attention - recall - language |
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Cholinesterase inhibitors bind IRREVERSIBLY or REVERSIBLY to AChE?
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Cholinesterase inhibitors bind REVERSIBLY to AChE?
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Memantine binds to ___ site in ion channel - it is an ___ inhibitor.
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Memantine binds to *Mg2+* site in ion channel - it is an *uncompetitive* inhibitor.
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Use of MAOI's, such as Selegiline, may improve memory & attention by increasing ___ (neurotransmitter).
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Use of MAOI's, such as Selegiline, may improve memory & attention by increasing *NE* (neurotransmitter).
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