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73 Cards in this Set
- Front
- Back
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WHat are the large inclusions in the nucleus of CM cells?
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Owl eye
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Is CMV DNA bigger or smaller than other Herpes viruses?
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larger
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Does the CMV have DNA and RNA?
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Yes, has DNA genome and mRNA
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In what cells deos replcation of cmv take place?
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fibroblasts, epithelial cells, and macrophages
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What is the duration of cmv infection befor cpe is apparent?
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4-6 weeks
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How are viral progeny tranmitted within the body?
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via infected lymphocytes and leuko cytes
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where are latent cmv infections established?
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in monocytes and certain marrow cells
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What are the 5 cmv disease possible categories?
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congenital, perinatal, transplant, normal, and immunosuppressed.
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Which fetal organs are targeted in CID?
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visceral organs
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How is CID transmitted?
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in utero from mother with no sx
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Which is a most common viral congenital infection, rubella or cmv?
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cmv, no vaccine
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what are the possible out comes of CID?
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still birth, liver and spleen, retardation, thrombocytopenia, rash, inapparrent infections
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How is the cmv usually shed?
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secretions
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In which transplant patients is cmv common?
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renal
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why is cmv infection so dire in transplant patients?
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concurrent immunosupression
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What causes unsusual manifestations of CMV?
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reactivation of latent disease by pregnancy or aids
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What cells serve to spread the diease to secondary sites?
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lymphocytes and monocytes
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What cells serve to spread the diease to secondary sites?
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lymphocytes and monocytes
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Can chronic carrier conditions be established even with inapparrent infection?
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yes
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10-15% OF KIDS UNDER WHAT AGE HAVE AB TO CMV?
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4 YEARS
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what percent of of adults > 35 years old have ab to cmv?
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80%
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What two avenue can cmv be cultured from children?
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saliva and urine
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Why is IgM in serum not a good indicator of primary cmv infection?
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because it is elevated in both primary and reactivation
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What other way is used to detect cmv infection?
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PCR
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What percent of neonates are infected with cmv?
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1%
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How does cmv infection proceed?
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cmv prohibits the expression of mhc I on apc's.
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How does ganciclovir work to treat cmv infection?
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It prevents cmv DNA replication by acting as a chain terminator or by negating the viral DNA pol activity
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Is there a vaccine for cmv?
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no
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what does the "o" in torch stand for?
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'other' - treponema pallidum, listeria monocytogenes
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How does the EB virus compare to other HHV?
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morphologically the same
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Where is EBV replication found?
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in lymphoblastoid cell lines
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Which cells are prone to EBV infection?
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B cells and certain epithelial cells that are CD21 (comp. C3d +).
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What acts as a receptor for EBV on B cells?
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CD21
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Which EBV antigens are not related to other HHV?
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Ag EBNA, VCA, MA, EA
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What are Ag EBNA?
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DNA binding proteins
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What is VCA?
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capsid proteins
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What is MA?
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membrane associated
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What is EA?
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early antigen
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What is the host range for EBV?
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Humans and no human primates?
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If competent T cells are present, what kind of EBV infection will occur?
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latent B cell infection
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What are the stages of protein sysnthesis in EBV infection of permissive cells?
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immeadiaately eearly, early, and late
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Which late glycoproteins are part of the envelop that enable attachement of the virus to spec ific recpetors?
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gp350/220
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What is particular about a circularized EBV genome?
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replicates in tandem with cell division and expresses only EBNAs and LPs
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Which EBV derived proteins promote and stimulate immortalization of B cells?
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Latent Membrane Proteins
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Can EBV cause a benign or malignant lymphoproliferative disease?
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yes, by acting usually as a cofactor?
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What diseases are usuallly linked with EBV?
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Burkitts Lymphoma
Mono - heterophile Ab + NasoPharyngeal carcinoma oral hairy laukoplakia in aids patients |
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Which proto-oncogene is possibly related to EBV induce lymphoma?
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MYC
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What is the term for large, atypical T lymphocytes that form on response to EBV infected B cells?
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Downey Cells in the Blood
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What corresponds to the immunological attack of T lymphocytes against EBV infected B cells, and cytokine production?
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disease Sx
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What are the 3 primary sx of EBV?
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lymphadenopathy
splenomegaly exudative pharyngitis |
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What is the name of short live Ab's that are not virus specific that are produced by infected B cells?
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heterophile antibodies
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What will heterophile Ab's do to non-human rbc's ?
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agglutinate them
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What % of EBV infected sera is positive for heterophile antibodies?
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60-80%
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Besides heterophile antibodies, what other immnune responses occur with EBV?
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specific antibdodies and T cells to infected B cells
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What does the monospot test look for?
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heterophile antibodies, agg = + test
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If EBV is heterophile -, what is done fo test?
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Ab detection to VCA (IgM), EA, MA, EBNA
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What is the time course for EBV interms of Ab expression?
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VCA (IgM) ---> VCA (IgG)----> EA +EBNA Ab's
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When is the Ab peak for EBV?
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few weeks post infection
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The presence of which Ab's indicate a past infection?
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EBNA with VCA (IgG)
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What is the treatment for EBV?
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no drugs approved
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EB genome is present in the epithelial call of what cancer?
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nasopharyngeal caricinoma
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What ethnic group will carry EBV in their epi cells?
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chinese males
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what happens in EBV infection if T cells are compromised?
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B cells go nuts
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What are other possible causes of chronic mono/viral fatigue syndrome?
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HHV 6 or retrovirus
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What causes exanthum subitum (roseola) and infects many children?
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HHV 6
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Is HHV6B related to other herpes viruses antigenically?
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No
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What does HHV6B infect?
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B and T cells and epi/endo as well as neurons
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What immune cells do HHV6B infect?
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latent infections in T cells
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Where is HHV6B found in high levels?
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saliva
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Which virus also causes roseola and is characterized by a high fever and a disseminated rash which FOLLOWS the fever, and lasts 24-48 hours?
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HHV7
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Which HHV is associated with Kaposi Sarcoma?
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HHV 8
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What cells are primarily infected by HHV8?
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B cells
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What does HHV do once inside?
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Encodes proteins with GF charcateristics and the ability to slow apoptosis of infercted and uninfected cells
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