Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
What type of histological finding is associated with CLL?
|
"smudge" cells
|
|
|
Guidelines for definitive diagnosis of CLL
|
1. lymphocytes > 5,000/ul
2. >30% marrow involvement 3. < 50% atypical immature lymphoid cells* 4. clonal expansions of abnormal cells *to distinguish from polymorphocytic leukemia |
|
|
Leading cause of death in patients with CLL
|
Infections
(CLL suppresses antibody production by plasma cells --> low circulating Ab and recurrent Infx with encapsulated organisms) |
|
|
CLL evolves into these malignancies
|
1.Richter's transformation: diffuse alrge cell immunoblastic lymphoma
2. Prolymphocytoid transformation--cells larger with distinct nucleoli less dense chromatin 3. Secondary malignancies (lung, GI) 4. AML |
|
|
A high rate of CD38+ cells in CLL correlates with ____
|
lower survival rates (unmutated)
|
|
|
Top two risk factors for low survival in CLL
|
1. Rai stage III/IV
2. deletion of 17p |
|
|
Treatment for CLL
|
fludarabine or chlorambucil work synergistically with Rituximab
Alemtuzumab (exceptionally myelo/immunosuppressive) HDCT + stem cell transplant |
