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11 Cards in this Set

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sample types to submit for overdosed patient
1. Blood: whole or serum;quantitative
2. Urine: broad spectrum screen; qualitative
3. Gastric fluid: direct search, identify parent drug
4. anything found with patient and clinical hx
drug screen:
Immunoassay
sensitive
specific
quick,cheap,automated
drug screen:
thin layer chromatography
broad spectrum
not sensitive
slow, unautomated
need expertise
drug screen:
negative report
need to search for other cause
general treatment of overdose
comatose: ABCDrugs
supportive: lavage,fluids.charcoal,pressor.cardiac monitor
antidote
rare:hemodialysis if Vd decreased(central compartment)
zer order:
constant AMOUNT eliminated in time
first order
Constant PERCENT
most drugs
\half life
steady state
repeated dosing
reached at 4 half lives(94%)
first order only
factors that change pharmacokinetics
renal fxn
liver fxn
saturation: no more half life;excretion becomes zero order/2dary routes form oxic metabolites
cfh
dfh
ethanol
-thought processes affected first
-disulfiram blocks ALDH causing buidup of acetaldehyde causing unpleasant effects
-zer order
-.01to.02% w/v/hr;induced to .03%
-ALDH incytosol
-microsomal(inducible)
-ethanoltoADH to acetaldehyde to ALDH to acetate